Results 11 to 20 of about 206,195 (300)
Head and neck squamous cell carcinoma [PDF]
Nature Reviews Disease Primers, 2020 Most head and neck cancers are derived from the mucosal epithelium in the oral cavity, pharynx and larynx and are known collectively as head and neck squamous cell carcinoma (HNSCC). Oral cavity and larynx cancers are generally associated with tobacco consumption, alcohol abuse or both, whereas pharynx cancers are increasingly attributed to infection ...
Johnson, Daniel E +5 more
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Head and Neck Squamous Cell Carcinoma: Epigenetic Landscape [PDF]
Diagnostics, 2020 Head and neck squamous carcinoma (HNSCC) constitutes the sixth most prevalent cancer worldwide. The molecular pathogenesis of HNSCC includes disorders in cell cycle, intercellular signaling, proliferation, squamous cell differentiation and apoptosis. In addition to the genetic mutations, changes in HNSCC are also characterized by the accumulation of ...
Kamila Romanowska +4 more
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PKM2 Modulation in Head and Neck Squamous Cell Carcinoma [PDF]
International Journal of Molecular Sciences, 2022 The enzyme pyruvate kinase M2 (PKM2) plays a major role in the switch of tumor cells from oxidative phosphorylation to aerobic glycolysis, one of the hallmarks of cancer. Different allosteric inhibitors or activators and several posttranslational modifications regulate its activity. Head and neck squamous cell carcinoma (HNSCC) is a common disease with
Verena Boschert +4 more
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Immunotherapy for Head and Neck Squamous Cell Carcinoma [PDF]
Current Oral Health Reports, 2016 Head and neck squamous cell carcinoma has been found to be an immunosuppressive malignancy, with many defects in the host immune system contributing to the progression of disease. A greater understanding of these defects has lead to the identification and investigation of new therapeutic strategies, targeting immune system dysfunction in an effort to ...
Rebecca C, Hoesli, Jeffrey S, Moyer
openaire +5 more sources
Immunotherapy for Head and Neck Squamous Cell Carcinoma [PDF]
Current Oncology Reports, 2018 Discussion of current strategies targeting the immune system related to solid tumors with emphasis on head and neck squamous cell carcinoma (HNSCC).This review will outline the current challenges with immunotherapy and future goals for treatment using these agents.Agents targeting immune checkpoint receptors (IR) such as program death 1 (PD1) have been
Moskovitz, Jessica +2 more
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Immunotherapy for Head and Neck Squamous Cell Carcinoma [PDF]
Hematology/Oncology Clinics of North America, 2015 Although head and neck squamous cell carcinoma has traditionally been considered to be a very immunosuppressive, or at least nonimmunogenic, tumor type, recent results from clinical studies of immune checkpoint blockade strategies have led to resurgence in the enthusiasm for immunotherapeutic approaches. Additional strategies for immunotherapy that are
David W, Schoppy, John B, Sunwoo
openaire +4 more sources
Does Notch play a tumor suppressor role across diverse squamous cell carcinomas? [PDF]
, 2016 The role of Notch pathway in tumorigenesis is highly variable. It can be tumor suppressive or pro-oncogenic, typically depending on the cellular context.
Biswas, Sangita +5 more
core +1 more source
Exosomes in Head and Neck Squamous Cell Carcinoma [PDF]
Frontiers in Oncology, 2019 Exosomes are small membranous vesicles that contain proteins, lipids, genetic material, and metabolites with abundant information from parental cells. Exosomes carry and deliver bioactive contents that can reprogram the functions of recipient cells and modulate the tumor microenvironment to induce pathological events through cell-to-cell communication ...
Cheng Xiao +5 more
openaire +3 more sources
Опухоли головы и шеи, 2019 Most of the malignant neoplasms of the head and neck are represented by squamous cell carcinoma. 18F-fluorodeoxyglucose positron emission tomography combined with computed tomography in squamous cell carcinoma of the head and neck is applied for primary ...
О. D. Ryzhova +6 more
doaj +1 more source
Induction chemotherapy in locally advanced squamous cell carcinoma of the head and neck: role, controversy, and future directions. [PDF]
, 2018 BackgroundThe value of induction chemotherapy (ICT) remains under investigation despite decades of research. New advancements in the field, specifically regarding the induction regimen of choice, have reignited interest in this approach for patients with
Cohen, EEW +6 more
core +1 more source