Results 221 to 230 of about 152,721 (288)

VEGF Expression in Head and Neck Squamous Cell Carcinoma: Association with TNM Staging and Tumor Progression. [PDF]

Curr Issues Mol Biol
Dumitru CS, Barb AC, Armega Anghelescu A, Novacescu D, Rakitovan M, Suciu CS, Zara F.   +6 more
europepmc   +1 more source

Artificial Intelligence for Identifying Tumor‐Reactive CD8+ T Cells: Biological Principles, Computational Advances, and Future Directions

Med Research, EarlyView.
This review details a three‐stage paradigm shift for tumor‐reactive CD8+ T‐cell identification: decoding transcriptomic states, deciphering clonal functional efficacy, and molecular‐level therapeutic TCR design. Addressing translational hurdles and generative AI “scientific blind spots”—such as missing catch bonds—we present a visionary roadmap.
Chao Yang, Yingying Sun, Yan Zhang, Yifen Shi, Zhiwen Shi   +4 more
wiley   +1 more source

PDS0101 With Pembrolizumab in HPV16-Positive Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma: A Phase 2 Nonrandomized Clinical Trial.

JAMA Oncol
Weiss J, Kaczmar J, Chintakuntlawar A, Worden FP, Mehra R, Kang H, Zinner RG, Arnold SM, Bhateja P, Harrington K, Gupta S, Zhao Y, Pham DC, Najeeb S, Kaur V, Sukari A, Giri A, Panella TJ, Grewal J, Galligan B, Nadler E, Grant C, Arteta-Bulos R, Noble DJ, Schaaf D, Price KAR.   +25 more
europepmc   +1 more source

Characterization of persistent HPV-specific activated T cells in head and neck squamous cell carcinoma. [PDF]

Oncoimmunology
Ishihara H, Shibata H, Muraoka D, Demachi-Okamura A, Okamoto T, Mizuta R, Fukushima Y, Sugita Y, Ogasawara A, Nishida R, Beppu S, Terada H, Nishikawa D, Suzuki H, Masago K, Sasaki E, Sakakura N, Yamaguchi R, Hanai N, Ogawa T, Matsushita H.   +20 more
europepmc   +1 more source

Organoid Coculture Models for Cancer Research and Immunotherapy

Med Research, EarlyView.
This review summarizes organoid coculture platforms, including submerged Matrigel culture, air–liquid interface, microfluidic/organoid‐on‐a‐chip, and 3D bioprinting, for reconstructing the tumor microenvironment to study tumor–stroma/immune crosstalk, evaluate immunotherapies, and enable drug screening.
Zhuo Yang, Huihui Yang, Guangxin Li, Guobang Liu, Zhulan Chen, Wenzhi Tian, Meiyang Huang, Xiaoling Liu, Yongsheng Zhao, Dong Chen   +9 more
wiley   +1 more source

Outcomes and Prognostic Factors of Cetuximab-Based Therapy in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma. [PDF]

J Clin Med
Dönmez Tekin M, Erdoğan AP, Şahbazlar M, Ekinci F.   +3 more
europepmc   +1 more source

Preoperatively Diagnosed Versus Undiagnosed Major Salivary Gland Cancer: Clinicopathological Characteristics, Treatment Strategies, and Oncological Outcomes

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To evaluate differences in clinicopathological characteristics, treatment strategies, and oncological outcomes between preoperatively diagnosed and undiagnosed major salivary gland cancers (MSGCs). Study Design Retrospective cohort study. Setting A single tertiary academic hospital. Methods Surgically confirmed MSGCs between 2012 and
Dongbin Ahn, Joseph Califano, Jihye Kwak, Sung Jae Heo, Kyu‐Yup Lee   +4 more
wiley   +1 more source

Pre-radiotherapy cachexia is associated with treatment discontinuation in patients with head and neck squamous cell carcinoma receiving definitive radiotherapy. [PDF]

Front Oncol
Guo Q, Sun Y, Ni Y, Li W, Wang L, Zhu M, Wu M.   +6 more
europepmc   +1 more source

Margin Status and Local Recurrence in Early‐Stage Oral‐Cavity Squamous Cell Carcinoma: Analysis of Reresection Outcomes

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To assess the impact of surgical margin status and re‐resection on local recurrence (LR) in early‐stage oral cavity squamous cell carcinoma (OCSCC). Study Design Retrospective analysis of 352 patients with cT1‐2N0 OCSCC. Setting Tertiary care center from 2005 to 2024.
Hannah J. Brown, Naomi C. Wang, Rahul Alapati, Uma Ramesh, Ameen M. Amanian, Andrés M. Bur   +5 more
wiley   +1 more source

Application of radiomics in head and neck squamous cell carcinoma. [PDF]

Transl Oncol
Wu S, Wang Z, Zhang Y, Chen Q, Liu H, Shen Y, Xiao J, Zhao L, Mao Y.   +8 more
europepmc   +1 more source