Results 181 to 190 of about 257,557 (304)

Role of the "In-Window" Craniectomy in the Management of Serious Head Trauma: 12 Case Series, Technical Note, Literature Review, and Comparison With Other Surgical Managements. [PDF]

Neurosurg Pract
Bulteau H, Poidevin P, Baroncini M.
europepmc   +1 more source

The E3 Ligase RNF115 Aggravates Pathological Cardiac Hypertrophy via Ubiquitin‐Mediated Degradation of SPTBN1

Advanced Science, EarlyView.
In response to hypertrophic stimuli, increased c‑JUN phosphorylation upregulates RNF115, leading to SPTBN1 ubiquitination and degradation. which promotes F‑actin depolymerization and YAP activation, driving cardiac hypertrophy. The RNF115 inhibitor DTD effectively suppresses SPTBN1 ubiquitination and cardiac hypertrophy.
Yan Zu, Shiqing Chen, Ji Chen, Liuliu Ruan, Bowen Li, Weijian Chu, Shichen Huang, Dian Yu, Jing Tian, Yuhan Zhao, Yi Han, Xin Tang, Yong Ji   +12 more
wiley   +1 more source

Point-of-care brain magnetic resonance imaging in children with head trauma (BRAINCHILD): Protocol for a prospective observational cohort study. [PDF]

PLoS One
Chaudhari PP, Guzman K, Toliao JM, Lozano S, Lee C, Shah P, Gonzalez F, De Souza BJ, Spurrier R, Chiarelli PA, Santoro JD, Durazo-Arvizu R, Doyle EK, Liu CJ, Nelson MD, Leporé N.   +15 more
europepmc   +1 more source

TDP‐43 Aggregation: The Healthy‐Toxic Balance of the Prion‐Like Domain

Advanced Science, EarlyView.
TDP‐43 function relies on a delicate balance between reversible phase‐separated states and irreversible aggregation. Under physiological conditions, TDP‐43 forms dynamic droplets and oligomers that support normal cellular functions. In pathological contexts, this balance shifts toward aberrant aggregation, leading to toxic species.
Luca Zangrando, Emanuele Buratti, Francesca Paron   +2 more
wiley   +1 more source

Abusive head trauma: a consensus statement on a shared workflow model within the Balkan network for quality improvement in forensic medicine. [PDF]

Front Pediatr
Concato M, Franzoni ML, Petrović T, Galic A, Srpanova VB, Dervisevic E, Spiliopoulou C, D'Errico S.   +7 more
europepmc   +1 more source

HLA‐DR+ Schwann Cells Generate the Protumor Cancer‐Neuron‐Immune Niche in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
Hijacked and educated by HNSCC cells, HLA‐DR+ Schwann cells lost their normal neural‐related functions but acquired immunoregulatory phenotypes to promote CD4+ T cells transform into Tregs. HLA‐DR+ Schwann cells induced a macrophage subpopulation, Il1β.
Xiaoyan Meng, Zhonglong Liu, Shijian Zhang, Luoman Gan, Liren Cao, Jingjing Sun, Lingfang Zhang, Yue He   +7 more
wiley   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Evaluating the Outcomes of Surgical Hip Dislocation for Femoral Head Trauma: A Systematic Review. [PDF]

Cureus
Hassan M, A Elnosh HA, Khidir Mohamed EN, Adam YAM, Ahmed AEE, Mohamedalhassan Abbas DM, Ahmed Omer OK.   +6 more
europepmc   +1 more source

Trauma, Seventh Edition

The definitive guide to trauma surgery-now in full color! The seventh edition, Trauma reaffirms its status as the leading comprehensive textbook in the field.
Mattox, Kenneth L., Moore, Ernest E., Feliciano, David V., Feliciano, David., Moore, Ernest.   +4 more
core  

Stiffness‐Activated Stellate Cells Drive Pancreatic Cancer Liver Colonization via GMFG‐TNS4 Signaling

Advanced Science, EarlyView.
Fibrotic liver stiffness activates hepatic stellate cells through Piezo1‐dependent calcium influx and ER stress, promoting EV‐associated GMFG release. Delivered GMFG engages TNS4 in pancreatic cancer cells, triggering FAK/AKT signaling, adhesion, and fatty acid synthesis.
Biwen Zhu, Jian Wan, Xue Zhang, Jiashuai Yan, Xi Chen, Xiaoqi Guan, Qianqian Ren, Tao Yang, Di Wu, Qingsong Guo, Yibing Guo, Yuhua Lu   +11 more
wiley   +1 more source