Results 121 to 130 of about 22,351 (309)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Prevention of postpartum depression via a digital acceptance and commitment therapy-based intervention: protocol for a pilot usability study

Frontiers in Psychiatry
IntroductionThe perinatal period — encompassing pregnancy and the first months after childbirth — is a time of increased psychological vulnerability. It is often associated with high levels of anxiety, stress and depression.
Silvia Rizzi, Anna Elena Nicoletti, Chiara De Luca, Stefania Poggianella, Carlo Dalmonego, Claudia Paoli, Debora Marroni, Barbara Burlon, Vanda Chiodega, Martina Dallafior, Riccardo Pertile, Silvia Rizzi, Laura Valentini, Irene Alberi, Stefano Forti, Fabrizio Taddei   +15 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Critical Comparative Study of Ayurvedic & Jyotishiya Body Measurements (Pramana) & Its Impact on Health & Wellbeing

National Journal of Research in Ayurved Science, 2019
‘Pramana’ is one of the body parameter which needs to be examined under ‘Ayu laxanas’ (body chararacteristics) for assessment of strength of the body as well as for futuristic outcome of health and wellbeing.  The Jyotish science is complimentary and contemporary to the Ayurvedic medical science.
openaire   +1 more source

Economic impact report on the New Zealand sport horse industry [PDF]

, 2012
The aim of this research paper is to gain an understanding of the size and scope of the sport horse industry in New Zealand. The definition of the sport horse industry is that it comprises of all horses in New Zealand that are not being used for the
Akoorie, Michèle E.M., Matheson, Alex
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Made in China: The international supply of illicit Semaglutide and weight-loss medicines online

Emerging Trends in Drugs, Addictions, and Health
Background: The use of GLP-1 medicines for weight-loss purposes is increasingly widespread. While these drugs are available as prescription medicines in the UK, there is an expansive illicit market for their supply operating online.
Luke A. Turnock, Evelyn Hearne, Lambros Lazuras   +2 more
doaj   +1 more source

Consent, confidentiality and the ethics of PAR in the context of prison research [PDF]

, 2012
Bailey, D, Ward, J
core   +1 more source