Results 101 to 110 of about 3,096,902 (313)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Effects of the introduction of a routine rotavirus vaccination programme on vaccination coverage and factors in a Japanese municipality: the VENUS Study

BMJ Public Health
Introduction Japan introduced a routine rotavirus vaccination programme in October 2020, and infants born in or after August 2020 were eligible to be vaccinated under full government subsidy. However, the effects of this programme on vaccination coverage
Haruhisa Fukuda, Megumi Maeda, Fumiko Murata   +2 more
doaj   +1 more source

An Introduction to Health Care Administrative Data

The Canadian Journal of Hospital Pharmacy, 2015
Health care administrative data are generated at every encounter with the health care system, whether through a visit to a physician’s office, a diagnostic procedure, an admission to hospital, or receipt of a prescription at a community pharmacy. The terms “health care utilization data”, “administrative health care billing records”, “administrative ...
Suzanne M, Cadarette, Lindsay, Wong
openaire   +3 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Leakage of Public Resources in the Health Sector: An Empirical Investigation of Chad [PDF]

In the public sector in developing countries, leakage of public resources could prove detrimental to users and affect the well-being of the population. In this paper, we empirically examine the importance of leakage of government resources in the health ...
Bernard Gauthier, Waly Wane
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Fragmentation in Mental Health Benefits and Services: A Preliminary Examination into Consumption and Outcomes [PDF]

, 2010
In this chapter, we examine consumption patterns and health outcomes within a health insurance system in which mental health benefits are administered under a carved-out insurance plan.
Grossman, Daniel, Richman, Barak D., Sloan, Frank   +2 more
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Advancing a new model of collaborative practice: a decade of Whole Health interprofessional education across Veterans Health Administration

BMC Medical Education
Large-scale implementation of interprofessional education across the United States Veterans Health Administration has supported advancement of a new model of collaborative practice, the Whole Health System, centering on the patient and what matters most ...
Theresa H. Liao, J. Adam Rindfleisch, Kelly Peyton Howard, Marc Castellani, Sara Grimsgaard Noyes   +4 more
doaj   +1 more source

Parental Perceptions of Oral Health and School-Based Dental Sealant Programs [PDF]

, 2016
Introduction: Community Health Needs Assessment (University of Vermont Medical Center, 2013) Identified oral health in pediatric population as a primary concern Barriers to dental care cited: access, affordability, education School-Based Sealant Program (
Cole, Julie, Davis, Wendy, Donnelly, Laura, Evans, Peter, Fontaine, Kristin, Grant, Ian, Imeda, Allicia, Kula, Daniel, Park, Clare, Wu, Hao Fang   +9 more
core   +1 more source