Results 31 to 40 of about 438,901 (276)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Technological arrangements for regulating access to healthcare: experience in the state of São Paulo [PDF]

Revista de Saúde Pública
OBJECTIVE To describe and analyze the regulatory arrangements used to expand access to beds and health services during Covid-19. METHODS This study, part of the Research for the SUS Program funded by Fundação de Amparo à Pesquisa do Estado de São ...
Mariana Prado Freire, Arthur Chioro, Luís Fernando Nogueira Tofani, André Luiz Bigal, Marília Cristina Prado Louvison   +4 more
doaj   +4 more sources

Personalized Care Management for Persons with Parkinson’s Disease

Journal of Parkinson’s Disease, 2020
There is a growing awareness that delivery of integrated and personalized care is necessary to meet the needs of persons living with Parkinson’s disease.
Angelika D. van Halteren, Marten Munneke, Eva Smit, Sue Thomas, Bastiaan R. Bloem, Sirwan K. L. Darweesh   +5 more
doaj   +1 more source

The Veterans Health Administration: Taking Home Telehealth Services to Scale Nationally [PDF]

, 2013
Since the 1990s, the Veterans Health Administration (VHA) has used information and communications technologies to provide high-quality, coordinated, and comprehensive primary and specialist care services to its veteran population.
Andrew Broderick
core  

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Care coordination for persons with mental health challenges: a scoping review

International Journal of Mental Health Systems
Background Care coordination is commonly employed to assist individuals with mental health challenges [MHCs]. However, its implementation in mental health contexts is inconsistent.
Anton N. Isaacs, Zoe Duncan
doaj   +1 more source

Regulatory technology arrangements for hospital bed access during the COVID-19 pandemic: scope review [PDF]

Cadernos de Saúde Pública
: The COVID-19 pandemic posed numerous challenges to health care systems, including hospital bed access. Analyzing the response provided and identifying regulatory technology arrangements that contributed to provide improved health care access can ...
Mariana Prado Freire, Arthur Chioro, Fernando Tureck, Luís Fernando Nogueira Tofani, Letícia Gabriela da Silva, André Luiz Bigal, Amanda da Cruz Santos Vieira, Marília Cristina Prado Louvison   +7 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

A scoping review of digital health technologies in multimorbidity management: mechanisms, outcomes, challenges, and strategies

BMC Health Services Research
Introduction Multimorbidity amplifies healthcare burdens due to the intricate requirements of patients and the pathophysiological complexities of multiple diseases.
Aklilu Endalamaw, Anteneh Zewdie, Eskinder Wolka, Yibeltal Assefa   +3 more
doaj   +1 more source