Results 51 to 60 of about 108,315 (229)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

The mental health care system for children and adolescents in Greece: a review and structure assessment

Frontiers in Health Services
BackgroundThe mental health system in Greece faces challenges to complete its transition to a community-oriented model, having significant concerns for child and adolescent care due to lower coverage and service gaps.
Lauro Estivalete Marchionatti, Lauro Estivalete Marchionatti, Lauro Estivalete Marchionatti, Julia Luiza Schafer, Julia Luiza Schafer, Vasiliki Eirini Karagiorga, Vasiliki Eirini Karagiorga, Panagiota Balikou, Andromachi Mitropoulou, Aspasia Serdari, Aspasia Serdari, Giorgos Moschos, Lilian Athanasopoulou, Maria Basta, Maria Basta, Maria Basta, André Simioni, André Simioni, Julian Vicenzi, Efstathia Kapsimalli, Alexandra Tzotzi, Sotiria Mitroulaki, Katerina Papanikolaou, Katerina Papanikolaou, Kalliopi Triantafyllou, Kalliopi Triantafyllou, Dimitra Moustaka, Shekhar Saxena, Sara Evans-Lacko, Christos Androutsos, Anastasia Koumoula, Giovanni Abrahão Salum, Giovanni Abrahão Salum, Giovanni Abrahão Salum, Konstantinos Kotsis, Konstantinos Kotsis, Konstantinos Kotsis   +36 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Analysis of the Internal Bed Regulation Committees from hospitals of a Southern Brazilian city

Einstein (São Paulo)
Objective To evaluate the composition of the Internal Regulation Committees created in hospitals of a capital city. Methods A cross-sectional descriptive study assessing the structure, processes and results of each Committee.
Vinícius Sabedot Soares
doaj   +1 more source

Care production for tuberculosis cases:analysis according to the elements of the Chronic Care Model

Revista da Escola de Enfermagem da USP, 2016
OBJECTIVE: To analyze the care provided to tuberculosis cases in primary health care services according to the elements of the Chronic Care Model. METHOD: Cross-sectional study conducted in a capital city of the northeastern region of Brazil involving ...
Daiane Medeiros da Silva, Hérika Brito Gomes de Farias, Tereza Cristina Scatena Villa, Lenilde Duarte de Sá, Maria Eugênia Firmino Brunello, Jordana de Almeida Nogueira   +5 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

New developments in health insurance: A step towards preventive health care [PDF]

Sestrinska reč, 2019
According to the proposal of the Law on Health Insurance, which entered the parliamentary procedure, patients who did not respond to the proposed preventive examinations and procedures will pay 35% of the treatment. Preventive health care is a compulsory
Trifković Nada
doaj  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source