Results 51 to 60 of about 443,849 (278)

Regulation and performance of health systems: a review of analytical frameworks*

Revista Panamericana de Salud Pública
The private health sector has expanded significantly in recent decades, both in Latin America and other regions. Governments and international organizations have dealt with this process in a heterogeneous manner.
Ernesto Báscolo, David Debrott Sánchez, Natalia Houghton, Carina Vance   +3 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Proposal of a Knowledge Management Model for Complex Systems: Case of the Supervision and Control Subsystem of the Colombian Health System

Journal of Market Access & Health Policy
Background: Considering regulatory, supervision, and control health policy, an innovative knowledge management model is proposed for the Colombian health system, which is recognized as a complex system.
Fredy G. Rodríguez-Páez, Diego Cabrera-Moya, Jorge Aurelio Herrera-Cuartas   +2 more
doaj   +1 more source

Assessing Needs of Care in European Nations. ENEPRI Policy Brief No. 14, 28 December 2012 [PDF]

, 2013
This Policy Brief presents the research questions, main results and policy implications and recommendations of the seven Work Packages that formed the basis of the ANCIEN research project, financed under the 7th EU Research Framework Programme of the ...
Mot, Esther, Willemé, Peter
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

A scoping review of the relational aspects of networks of care for maternal and newborn health: informing a revised operational framework

Discover Public Health
Objective We investigated the relational aspects of the “Networks of Care” (NOC) approach to define their role and highlight their importance. These relational aspects distinguish NOCs from other health system-strengthening approaches that aim to enhance
Olufunke Fasawe, Alisa Jenny, Stefano Bertozzi, Katherine Kalaris, Robyn Churchill, Ndola Prata, Dennis Matheka Mulwa, Marite Vergara, Andy Elizabeth Carmone, Allisyn Moran, Dilys Walker   +10 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Early Alzheimer's disease patient care pathway and health system readiness: A framework for integrated care

Alzheimer’s & Dementia: Translational Research & Clinical Interventions
Alzheimer's disease (AD) is often underdiagnosed, especially at early stages when symptoms are mild, and patients may benefit from new and recently approved anti‐amyloid therapies.
Ilya M. Nasrallah, Cate Polacek, Feride H. Frech, Pierre N. Tariot, Jeff Vawter, Yuval Zabar, Christine Divers, Whoy Y Shang, David S. Geldmacher, Michele Towman, Heather Reiter, Cindy D. Marshall, Valeria Baldivieso, Daryl Rhys Jones, Erik S. Musiek, Hideki Toyosaki, Babak Tousi   +16 more
doaj   +1 more source

Monitoring and management of chronic kidney disease in ambulatory care – analysis of clinical and claims data from a population-based study

BMC Health Services Research, 2022
Background Although chronic kidney disease (CKD) is highly prevalent in the general population, little research has been conducted on CKD management in ambulatory care.
Gesine Weckmann, Janine Wirkner, Elisa Kasbohm, Carolin Zimak, Annekathrin Haase, Jean-François Chenot, Carsten Oliver Schmidt, Sylvia Stracke   +7 more
doaj   +1 more source