Results 141 to 150 of about 14,647,476 (261)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

The health consequences of politically-induced trauma. [PDF]

PLOS Ment Health
Horwitz RI.
europepmc   +1 more source

The Surgeon General Report on Reducing the Health Consequences of Smoking : 25 Years of Progress : Executive Summary

This supplement to the MMWR (Volume 38, No. S-2) is a reprint of the Executive Summary of the Surgeon General's report enttitled Reducing the health consequences of smoking: 25 years of progress, released Jaunuary 1989. The report is included in the MMWR

core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Potential Health Consequences of Regular Blood Donation: Current Evidence and Remaining Uncertainties. [PDF]

J Clin Med
Berli S, Kaiser MS, Schindler E, Tsakiris DA.   +3 more
europepmc   +1 more source

Health consequences of smoking\u201450 years of progress [PDF]

This report is divided into three sections. Section 1 \u201cHistorical perspective, overview, and conclusions\u201d pro- vides an overall summary of the report and its conclusions.

core  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Biological Mechanisms Underlying the Adverse Health Consequences of Human Circadian Misalignment from Night Shift Work. [PDF]

Curr Sleep Med Rep
Lundholm KR, Satterfield BC, Banks S, Liu PY, Kombala CJ, Hurtado-Alvarado G, Greer AJ, Muck RA, Layton MA, Du D, Gaddameedhi S, Van Dongen HPA.   +11 more
europepmc   +1 more source

Northern Territory Mental Health Service Strategic Plan 2015 - 2021

, 2015
The Plan sets priorities to support and increase the capacity of the mental health system to meet the needs of mental health consumers in the Northern ...
Department of Health
core  

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source