Results 91 to 100 of about 582,325 (288)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
The Brain Disorders Debate, Chekhov, and Mental Health Humanities. [PDF]
J Med Humanit, 2023 Valtonen J, Lewis B.
europepmc +1 more source
BMJ, 2000 News p 1178 Over the past few weeks England and Wales have endured the most widespread flooding for more than 50 years. By the end of the first week of November more than 3000 homes had been flooded and transport had been disrupted; in some areas water supplies have been contaminated, and a hospital has been evacuated.1 Flooding accounts for 40% of ...
C A, Ohl, S, Tapsell
openaire +3 more sources
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Research and Humanities in Medical Education, 2020 DNAR stands for 'Do Not Attempt Resuscitation' which indicates that a person does not want to receive cardiopulmonary resuscitation or advanced medical care at the end of life when, in the specific case, the patient believes it may do more harm than good.
Kamna Kakkar
doaj
Creating Health Humanities Programs at Liberal Arts Colleges: Three Models. [PDF]
J Med Humanit, 2023 Hausman BL +4 more
europepmc +1 more source
, 2010 Coming Up Taller is a report filled with hope, a narrative about youth learning to paint, sing, write plays and poems, take photographs, make videos and play drums or violins.
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