Results 121 to 130 of about 582,325 (288)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Novels as data: Health humanities and health psychology. [PDF]
J Health Psychol, 2022 Kaptein AA.
europepmc +1 more source
The Summit on Creativity and Aging in America [PDF]
, 2016 This report looks at how the federal government can leverage the arts to foster healthy aging and inclusive design for this growing population. This white paper features recommendations from the May 2015 Summit on Creativity and Aging in America, a ...
Ace Everett +7 more
core
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Developing New Academic Programs in the Medical/Health Humanities: A Toolkit to Support Continued Growth. [PDF]
J Med Humanit, 2021 Klugman CM +4 more
europepmc +1 more source
Mapping metaphors of wealth and want: a digital approach [PDF]
, 2014 The AHRC-funded Mapping Metaphor with the Historical Thesaurus project aims to provide data on the extent and development of metaphor across the history of English.
Alexander, Marc, Bramwell, Ellen
core
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Bodies in transit: trauma, health and exile in Dima Wannous’s The Frightened Ones
Cogent Arts & HumanitiesThis study examines how forced migration and displacement impact both physical and psychological health, taking Dima Wannous’s The Frightened Ones as a representative example.
Kawthar Y. Alothman
doaj +1 more source