Results 41 to 50 of about 53,240 (282)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Conicity Index Associated with Adult Hearing Impairment: A Cross-Sectional Study Based on the National Health and Nutrition Examination Survey (2001–2018)

Noise and Health
Objective: This study aimed to evaluate the association of conicity index (C-index), a marker of abdominal obesity, with hearing impairment (HI) in US adults using data from the National Health and Nutrition Examination Survey (NHANES).
Guifen Cai, Xiaoyan Xu, Xiaokun Li, Qiong Fang   +3 more
doaj   +1 more source

Development of one general and six country-specific algorithms to assess societal health utilities based on ASAS HI

, 2019
Objective Health utilities represent preference values that persons attach to health states. This study aims to develop one general and six country-specific algorithms to calculate societal preference values for health of patients with spondyloarthritis (
Mickael Hiligsmann, Kiltz, U., Bansback, N., Kiltz, Uta, Essers, I., Hiligsmann, M., Boonen, A., Braun, J., van Der Heijde, Desiree, Nick Bansback, Heijde, D. van der, Braun, Juergen, Boonen, Annelies, Annelies Boonen, Essers, Ivette, Désirée van der Heijde, Juergen Braun, Uta Kiltz, Hiligsmann, Mickael, Bansback, Nick, Ivette Essers   +20 more
core   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Anemia risk in relation to lead exposure in lead-related manufacturing

, 2017
[[abstract]]Background: Lead-exposed workers may suffer adverse health effects under the currently regulated blood lead (BPb) levels. However, a probabilistic assessment about lead exposure-associated anemia risk is lacking. The goal of this study was to
Hsieh, NH;Chung, SH;Chen, SC;Chen, WY;Cheng, YH;Lin, YJ;You, SH;Liao, CM
core   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

The Effect of Health Education to Community Knowledge and Aedes aegypti Density in Bayah Subdistrict, Banten Province

Makara Journal of Health Research, 2011
Dengue Haemorrhagic Fever (DHF) is a public health problem in Bayah, Banten Province thus, control of mosquitoes breeding sites (CMBS) and health education is necessary.
Saleha Sungkar, Rawina Winita, Agnes Kurniawan   +2 more
doaj   +1 more source

OP0214 Development of a Health Index in Patients with Ankylosing Spondylitis (ASAS HI) – Final Result of a Global Initiative Based on the ICF Guided by ASAS

Annals of the Rheumatic Diseases, 2013
Background The impact of ankylosing spondylitis (AS) on a patient’s life can be considerable. The International Classification of Functioning, Disability and Health (ICF) is a model to systematically classify and describe functioning, disability, and health in human beings.
Kiltz, U, van der Heijde, D, Boonen, A, Cieza, A, Stucki, G, Khan, MA, Maksymowych, W, Marzo-Ortega, H, Reveille, J, Taylor, W, Bostan, C, Braun, J   +11 more
openaire   +2 more sources

Ecological and Health Risk Assessments of an Abandoned Gold Mine (Remance, Panama): Complex Scenarios Need a Combination of Indices [PDF]

, 2021
The derelict Remance gold mine is a possible source of pollution with potentially toxic elements (PTEs). In the study area, diverse mine waste has been left behind and exposed to weather conditions, and poses risks for soil, plants and water bodies, and ...
Martínez, Ernesto, Eva María García-Noguero, Miguel Vargas-Lombardo, Gutiérrez, Eric, Rosario García-Giménez, Francisco Jesús García-Navarro, Eric Gutiérrez, Efrén Garcia-Ordiales, García-Navarro, Francisco Jesús, Arrocha, Jonatha, Higueras, Pablo, García Giménez, Rosario, Vargas-Lombardo, Miguel, Campos, Juan Antonio, José María Esbrí, Ernesto Martínez, Garcia-Ordiales, Efrén, Pablo Higueras, Esbrí, José María, Jiménez Ballesta, Raimundo, Ana Cristina González-Valoys, González-Valoys, Ana Cristina, García-Noguero, Eva María, Juan Antonio Campos, Raimundo Jiménez-Ballesta, Jonatha Arrocha, Tisla Monteza-Destro, Monteza-Destro, Tisla   +27 more
core   +1 more source