Results 101 to 110 of about 27,588,902 (257)

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Factors Influencing Progress of Health Information Exchange Organizations in the United States [PDF]

, 2017
Progress is being made toward improved healthcare interoperability in the United States, but exchange between electronic health records alone is insufficient.
Li, Xiouchun, Overhage, J. Marc, Covich-Bordenick, Jennifer, Overhage, Lauren M.   +3 more
core   +1 more source

Identifying patients at risk of suicide using data from health information exchanges

BMC Public Health
Background Suicide is within the top 10 causes of death in the US and rates have increased over 30% in the last two decades. Identifying suicide risk in healthcare settings has become a national priority and predicting risk using statistical models has ...
Shane J. Sacco, Kun Chen, Jun Jin, Boyang Tang, Fei Wang, Robert H. Aseltine   +5 more
doaj   +1 more source

Electronic health information exchange in underserved settings: examining initiatives in small physician practices & community health centers [PDF]

, 2014
: Background Health information exchange (HIE) is an important tool for improving efficiency and quality and is required for providers to meet Meaningful Use certification from the United States Centers for Medicare and Medicaid Services.

core   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Other title: Update on Health Information Technology / Health Information Exchange

, 2009
application/pdf; "November 20, 2009."; Testimony before the Kansas Legislature, HCBS Oversight Committee, by Doug Farmer, Deputy Director, Kansas Health Policy Authority.Testimony giving an overview of KHPA's role in managing and implementing ...
Farmer, Doug.
core   +1 more source

Design, implementation, and comprehensive evaluation of the specialized teachings of health information technology students

Journal of Education and Health Promotion
Background: There is an increasing need for a comprehensive assessment method to assess the various essential skills of Health Information Technology (HIT) students.
Mohammad Hosein Hayavi-Haghighi, Zahra Mastaneh, Farid Khorrami, Mehraban Shahi, Nasrin Davaridolatabadi   +4 more
doaj   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source