Results 81 to 90 of about 2,058,259 (297)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The effects of interoperable information technology networks on patient safety: a realist synthesis

Health Services and Delivery Research, 2020
Background: Interoperable networks connect information technology systems of different organisations, allowing professionals in one organisation to access patient data held in another one.
Justin Keen, Maysam Abdulwahid, Natalie King, Judy Wright, Rebecca Randell, Peter Gardner, Justin Waring, Roberta Longo, Silviya Nikolova, Claire Sloan, Joanne Greenhalgh   +10 more
doaj   +1 more source

Definitions, components and processes of data harmonisation in healthcare: a scoping review

BMC Medical Informatics and Decision Making, 2020
Background Data harmonisation (DH) has emerged amongst health managers, information technology specialists and researchers as an important intervention for routine health information systems (RHISs).
Bey-Marrié Schmidt, Christopher J. Colvin, Ameer Hohlfeld, Natalie Leon   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Machine Learning Approaches to Identify Nicknames from A Statewide Health Information Exchange [PDF]

, 2019
Patient matching is essential to minimize fragmentation of patient data. Existing patient matching efforts often do not account for nickname use. We sought to develop decision models that could identify true nicknames using features representing the ...
Grannis, Shaun J., Kasthurirathne, Suranga N.   +1 more
core   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Talking together : consumer communities in healthcare [PDF]

, 2004
Consumer involvement in computer mediated communities (CMCs) is increasing particularly in high involvement services such as healthcare. This paper examines the role of CMCs as providers of patient information and support and the subsequent effect on the
Hogg, Gillian, Laing, Angus, Newholm, Terry   +2 more
core   +1 more source

Soft networks for bridging the gap between research and practice: illuminative evaluation of CHAIN [PDF]

, 2004
Objectives To explore the process of knowledge exchange in an informal email network for evidence based health care, to illuminate the value of the service and its critical success factors, and to identify areas for improvement.Design Illuminative ...
Boynton, P, Greenhalgh, T, Rigby, M, Russell, J   +3 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Quality and Safety Aspects of Infant Nutrition [PDF]

, 2012
Quality and safety aspects of infant nutrition are of key importance for child health, but oftentimes they do not get much attention by health care professionals whose interest tends to focus on functional benefits of early nutrition.
Agostoni C, Agostoni C, Agostoni C, Aris B, Berthold Koletzko, Bier DM, Birlouez-Aragon I, Bonerba E, Cahill SM, Chang H, Dabeka R, Davanzo R, Day JB, Dewey KG, Domellof M, El-Tras WF, Erkekoglu P, Fattal-Valevski A, Fattal-Valevski A, Fattal-Valevski A, Fewtrell MS, Fewtrell MS, Flores JP, Friedman M, Gossner CM, Guzel A, Hamrin P, Hernell O, Hilbig A, Hirvonen T, Jongenburger I, Kaleita TA, Khlangwiset P, Kim SA, Koletzko B, Koletzko B, Koletzko B, Kornreich L, Kvist LJ, Lanska DJ, Lönnerdal B, Malloy MH, Margaret Ashwell, Miled RB, Mitkus RJ, Newberry RE, Norberg S, Oluwafemi F, Panfeng S, Pavesi Arisseto A, Raanan Shamir, Raecker T, Rebhan B, Reij MW, Ruiz E, Santillana MI, Schoder D, Shamir R, Silver LB, Simoneau C, Simoneau C, Snijder CA, Snijder CA, Szajewska H, Szajewska H, Turck D, Weistaub G, Welch RW, Whyatt RM, Willoughby A, Yen TH, Zlotkin S   +71 more
core   +1 more source