Results 71 to 80 of about 27,588,902 (257)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
The effects of interoperable information technology networks on patient safety: a realist synthesis
Health Services and Delivery Research, 2020 Background: Interoperable networks connect information technology systems of different organisations, allowing professionals in one organisation to access patient data held in another one.
Justin Keen +10 more
doaj +1 more source
A Tentative Discussion of the Limitations of Health Information on the Internet in Taiwan [PDF]
, 2009 [[abstract]]Health information on the internet is important for consumers. Recently, the need to evaluate websites for the content quality of health information that may increase benefits to the public has been identified in most countries of Europe and ...
CHIH-PING LI
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Rolling summary of the evidence in relation to the Omicron (B.1.1.529) variant
, 2021 On 26 November 2021, the World Health Organization (WHO) designated the variant B.1.1.529 a variant of concern (VOC) named ‘Omicron’.(1) Further information on the epidemiological events leading up this designation is detailed in a Science Brief ...
Health Information and Quality Authority (HIQA)
core
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
Frontiers in Genetics, 2018 Genome and other data are already being used in areas including cancer and rare diseases. Data-sharing and secondary uses are likely to become much broader and far more extensive; thus, obtaining proper consent for these new uses of data is an important ...
Atsushi Kogetsu +2 more
doaj +1 more source
, 2022 At the request of the Department of Health, HIQA undertook a descriptive analysis of epidemiological indicators in order to describe the burden of COVID-19 as it has occurred across a range of European countries from 1 January 2020 up to 30 November ...
Health Information and Quality Authority (HIQA)
core