Results 61 to 70 of about 27,588,902 (257)

The Indiana Learning Health System Initiative: Early experience developing a collaborative, regional learning health system

Learning Health Systems, 2021
Introduction Learning health systems (LHSs) are usually created and maintained by single institutions or healthcare systems. The Indiana Learning Health System Initiative (ILHSI) is a new multi‐institutional, collaborative regional LHS initiative led by ...
Titus Schleyer, Linda Williams, Jonathan Gottlieb, Christopher Weaver, Michele Saysana, Jose Azar, Josh Sadowski, Chris Frederick, Siu Hui, Areeba Kara, Laura Ruppert, Sarah Zappone, Michael Bushey, Randall Grout, Peter J. Embi   +14 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Connecticut health information technology and exchange strategic and operational plan

, 2010
Dec. 2010 rev.; Title from PDF cover (publisher's Web site, viewed Dec. 20, 2010).; Preceded by draft ed.: Health information technology exchange of Connecticut strategic plan. [Hartford] : Connecticut Dept.

core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

¹⁸F-prostate-specific membrane antigen (PSMA) PET/CT imaging for the staging of high-risk or recurrent prostate cancer: Evidence synthesis to support a generic justification decision [PDF]

, 2023
Prostate cancer is the most common cancer in men. As part of their care, patients diagnosed with prostate cancer can have different kinds of imaging (scans) to find out whether their cancer is confined to the prostate or whether it has spread to other ...
Health Information and Quality Authority (HIQA)
core  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Use of My Health Record by Clinicians in the Emergency Department: An Analysis of Log Data

Frontiers in Digital Health, 2021
Objectives: Leverage log data to explore access to My Health Record (MHR), the national electronic health record of Australia, by clinicians in the emergency department.Materials and Methods: A retrospective analysis was conducted using secondary ...
Alexandra K. Mullins, Heather Morris, Joanne Enticott, Michael Ben-Meir, David Rankin, Kumar Mantripragada, Helen Skouteris, Helen Skouteris   +7 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Duration of immunity (protection from reinfection) following SARSCoV-2 infection [v8.0]

, 2021
The Health Information and Quality Authority (HIQA) has developed a series of evidence syntheses to inform advice from HIQA to the National Public Health Emergency Team (NPHET). The advice takes into account expert interpretation of the evidence by HIQA’
Health Information and Quality Authority (HIQA)
core