Results 91 to 100 of about 447,143 (299)

Health Information Exchange to Support a Prescription Drug Monitoring Program

INNOVATIONS in Pharmacy, 2015
Objective: To describe barriers to the utilization of a query based Health Information Exchange (HIE) that supports a statewide Prescription Drug Monitoring Program (PDMP).
Gary L. Cochran, Donald G. Klepser, Marsha Morien, Lina Lander   +3 more
doaj   +1 more source

The effects of interoperable information technology networks on patient safety: a realist synthesis

Health Services and Delivery Research, 2020
Background: Interoperable networks connect information technology systems of different organisations, allowing professionals in one organisation to access patient data held in another one.
Justin Keen, Maysam Abdulwahid, Natalie King, Judy Wright, Rebecca Randell, Peter Gardner, Justin Waring, Roberta Longo, Silviya Nikolova, Claire Sloan, Joanne Greenhalgh   +10 more
doaj   +1 more source

Health information exchange and patient safety

Journal of Biomedical Informatics, 2007
One of the most promising advantages for health information exchange (HIE) is improved patient safety. Up to 18% of the patient safety errors generally and as many as 70% of adverse drug events could be eliminated if the right information about the right patient is available at the right time. Health information exchange makes this possible.
David C. Kaelber, David W. Bates
openaire   +2 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A one-stop shop for health information [PDF]

Funding Information: The InfAct project received funding from the European Union's Health Programme (2014-20) under grand agreement No 801553 InfAct, and PHIRI received funding from The European Union's Horizon 2020 research and innovation programme ...
Peyroteo, Mariana, Bogaert, Petronille, M. Saso, Population Health Information Research Infrastructure and the Health Information Portal, Habl, Claudia, Velez Lapão, Luís, Tolonen, Hanna, Unim, Brigid, H. Tolonen, M. Peyroteo, B. Unim, L.,Luís Velez, Palmieri, Luigi, Saso, Miriam, Faragalli, Andrea, Lapão, Luís Velez, C. Habl, P. Bogaert, Schutte, Nienke, L. Palmieri, N. Schutte   +20 more
core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Measuring Population Health Using Electronic Health Records: Exploring Biases and Representativeness in a Community Health Information Exchange [PDF]

, 2015
Assessment is a core function of public health. Comprehensive clinical data may enhance community health assessment by providing up-to-date, representative data for use in public health programs and policies, especially when combined with community-level
Gibson, P. Joseph, Rosenman, Marc, Dixon, Brian E., Comer, Karen Frederickson   +3 more
core   +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Authentication of Patients and Participants in Health Information Exchange and Consent for Medical Research: A Key Step for Privacy Protection, Respect for Autonomy, and Trustworthiness

Frontiers in Genetics, 2018
Genome and other data are already being used in areas including cancer and rare diseases. Data-sharing and secondary uses are likely to become much broader and far more extensive; thus, obtaining proper consent for these new uses of data is an important ...
Atsushi Kogetsu, Soichi Ogishima, Kazuto Kato   +2 more
doaj   +1 more source