Results 61 to 70 of about 1,930,376 (345)

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

Determining the Components of a Health Information Social Network Based on a Delphi Study

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2021
Background and Objectives: In recent years, social networks have been considered by organizations active in the health sector. They have provided many opportunities for consulting, training, and information sharing and held promises to increase the ...
Akbar Mohammadi Motlaq, Zahra Abazari, Fereshteh Sepehr   +2 more
doaj  

Accessing and sharing health information for post-discharge stroke care through a national health information exchange platform - a case study

BMC Medical Informatics and Decision Making, 2019
Background Patients and citizens need access to their health information to get a retrospective as well as a prospective view on their care and rehabilitation processes.
Nadia Davoody, Sabine Koch, Ingvar Krakau, Maria Hägglund   +3 more
doaj   +1 more source

Data validation for healthcare cost analysis in STROKE OWL

GMS Medizinische Informatik, Biometrie und Epidemiologie, 2020
The STROKE OWL project applies a new approach of cross-sector care management for strokes and determines the costs of this new approach. An evaluator determines the current costs of stroke care for the health insurance companies involved in the project ...
Wolters, Timo, Michelsen, Timo, Lüpkes, Christian, Hein, Andreas   +3 more
doaj   +1 more source

Applying Multiple Data Collection Tools to Quantify Human Papillomavirus Vaccine Communication on Twitter. [PDF]

, 2016
BACKGROUND: Human papillomavirus (HPV) is the most common sexually transmitted infection in the United States. There are several vaccines that protect against strains of HPV most associated with cervical and other cancers.
Budenz, Alexandra, Fisher, Kara, Klassen, Ann C., Leader, Amy, Massey, Philip M., Yom-Tov, Elad   +5 more
core   +3 more sources

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Molecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella, Giuseppina Comito, Luigi Ippolito, Erica Pranzini, Marta Iozzo, Giulia Gangarossa, Francesca Virgilio, Silvia Bua, Alessio Nocentini, Giada Sandrini, Nicla Lorito, Marina Bacci, Gabriella Nesi, Pietro Spatafora, Sergio Serni, Claudiu T. Supuran, Andrea Morandi, Paola Chiarugi, Elisa Giannoni   +18 more
wiley   +1 more source

Biophysical characterization and ion transport with cell‐based and proteoliposome reconstitution assays of invertebrate K+‐Cl− cotransporters

FEBS Open Bio, EarlyView.
The K+‐Cl− cotransporters (KCCs) facilitate the symport of ions across the plasma membrane. They participate in physiological processes including neuronal regulation. Here, we characterized KCCs from Drosophila and Hydra vulgaris. Comparative analyses of transporters provide insights into the mechanism of KCC ion transport, regulation, and evolution ...
Satoshi Fudo, Marina Verkhovskaya, Coralie Di Scala, Claudio Rivera, Tommi Kajander   +4 more
wiley   +1 more source

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

Measuring Population Health Using Electronic Health Records: Exploring Biases and Representativeness in a Community Health Information Exchange [PDF]

, 2015
Assessment is a core function of public health. Comprehensive clinical data may enhance community health assessment by providing up-to-date, representative data for use in public health programs and policies, especially when combined with community-level
Comer, Karen Frederickson, Dixon, Brian E., Gibson, P. Joseph, Rosenman, Marc   +3 more
core   +1 more source

Health information exchange policy and evaluation

Journal of Biomedical Informatics, 2007
Concerns about the quality, safety, and cost of healthcare have driven the nation to increase its focus on this issue. A number of states are moving forward-in parallel with federal efforts-to develop and adopt policies for improving health and healthcare through health information technology and electronic health information exchange.
openaire   +3 more sources