Results 121 to 130 of about 665,485 (268)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Post-market quality monitoring of medicines in Christian Health Association of Ghana health institutions. [PDF]

Ghana Med J
Arhinful DK, Yeboah P, Duah J, Antwi MA, Attachey A, Karikari-Boateng E, Awal AM, Rinke de Wit TF, Kretchy IA.   +8 more
europepmc   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Prevalence of paediatric diarrhoea in Arba minch government health institutions, Southern Ethiopia and associated factors. [PDF]

Sci Rep
Mengistu M, Woldemariam M, Manilal A, Aklilu A, Yohannes T, Idhayadhulla A, Alodaini HA.   +6 more
europepmc   +1 more source

Royal Sanitary Institute Health congress [PDF]

American Journal of Public Health and the Nations Health, 1935
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Analysis of Vector Mosquito Control Status Using Insecticide Purchase Data from Public Health Institutions in the Republic of Korea (2019-2023). [PDF]

Jugan Geongang Gwa Jilbyeong
Jang CW, Kim GH, Cho SR, Lee HI.
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Timing of first prenatal ultrasound and associated factors among women who gave birth at health institutions in Ambo Town, central Ethiopia. [PDF]

PLoS One
Mesfin S, Bulto GA, Gutu M, Gemeda ND.
europepmc   +1 more source

The SAFE (Social Accountability as the Framework for Engagement) for Health Institutions project: Rapid evidence narratives. [PDF]

Can Fam Physician, 2023
Anawati A, Ramsoondar N, Cameron E.
europepmc   +1 more source