Results 131 to 140 of about 665,485 (268)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Etiologic Types and Complications of Diabetes Mellitus in Newly Diagnosed Patients at Health Institutions in Bulawayo, Zimbabwe: Protocol for a Cross-Sectional and Prospective Observational Study. [PDF]

JMIR Res Protoc
Gwini R, Sibanda E, Mwembe D, Pirie FJ, Motala AA.   +4 more
europepmc   +1 more source

Research on the influence path of the unit environment of medical and health institutions on achievement transformation output. [PDF]

PLoS One, 2023
Gao Y, Gu H.
europepmc   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The effects of social media criticism against public health institutions on trust, emotions, and social media engagement. [PDF]

Proc Natl Acad Sci U S A
Lee JY.
europepmc   +1 more source

Health providers readiness in managing intimate partner violence in public health institutions, Ethiopia. [PDF]

PLoS One, 2023
Teshome L, Adugna H, Deribe L.
europepmc   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Magnitude of tuberculosis treatment outcomes and associated factors in public health institutions of Arba Minch town, Southern Ethiopia: A multi-centered retrospective cross-sectional study. [PDF]

PLoS One
Asmamaw B, Tadese TT, Mamo RY, Taye BA, Azale AW, Wondmeneh YC, Shibeshi DN, Bortequaye EB, Ziza TT, Bolliso TE, Tekalign T, Guadie A.   +11 more
europepmc   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Geophagy as a risk factor for Soil-transmitted helminthic infections among pregnant women attending antenatal care at health institutions in Chiro Town, Eastern Ethiopia. [PDF]

BMC Pregnancy Childbirth
Mesfin A, Ayana M, Getachew M, Mekonnen Z.   +3 more
europepmc   +1 more source