Results 101 to 110 of about 1,408,925 (327)
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Estimate of hidden prevalence of leprosy in the Diamantina micro-region - Minas Gerais
Revista Eletrônica de Enfermagem, 2014 This study sought to estimate the hidden prevalence of leprosy in the Diamantina micro-region, using the methodology proposed by the Pan-American and World Health Organizations.
Gabriela de Cássia Ribeiro +4 more
doaj +1 more source
Tracking Chart 2009 Nike, Inc., Vietnam, Factory 2 [PDF]
, 2009 This document is part of a digital collection provided by the Martin P. Catherwood Library, ILR School, Cornell University, pertaining to the effects of globalization on the workplace worldwide.
Fair Labor Association
core +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Building the Blue Economy: Opportunities for Community-Based Organizations in Stormwater Management [PDF]
, 2016 The United States has a serious problem with combined sewer overflows. In responding to this environmental and public health menace, many regions are using innovative “green infrastructure” or “blue economy” approaches in addition to traditional “gray ...
Kaminsky, Jen +3 more
core +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Perspectiva bioética do modelo de assistência suplementar no Brasil
Revista BioéticaEste artigo apresenta os resultados de estudo voltado aos planos e seguros privados de saúde, denominado de assistência suplementar, regulamentados no Brasil há mais de uma década para solucionar conflitos na prestação de serviços.
Regina R.P. Carvalho +2 more
doaj
Generic Continuity of Operations/Continuity of Government Plan for State-Level Transportation Agencies, Research Report 11-01 [PDF]
, 2011 The Homeland Security Presidential Directive 20 (HSPD-20) requires all local, state, tribal and territorial government agencies, and private sector owners of critical infrastructure and key resources (CI/KR) to create a Continuity of Operations ...
Edwards, Frances L. +2 more
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source