Results 121 to 130 of about 134,023 (290)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Health Care Financing Reform: Issues and Updates [PDF]
Generation of funds and its efficient utilization have remained as a challenge to health authorities. This issue presents the recent efforts on health care financing as well as the concerns regarding its coverage, efficiency and sustainability.
Health Policy Development Staff (DOH)
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
An act relating to the application of the open meetings law to certain health maintenance organizations [PDF]
, 2003 Bill introduced by the Texas Senate relating to the application of the open meetings law to certain health maintenance ...
Texas. Legislature. Senate.
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Salāmat-i kār-i Īrān, 2018 Background and aims: Radio frequency and microwaves radiations are a part of non-ionizing electromagnetic radiation that have various applications in different work environments.
Ali Khavanin +3 more
doaj
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Blue Cross has decided to enter the Health Maintenance Organizations (HMO) busin [PDF]
, 1984 Blue Cross has decided to enter the Health Maintenance Organizations (HMO) business.
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
An act relating to appeals of adverse determinations made by health maintenance organizations [PDF]
, 2003 Bill introduced by the Texas Senate relating to appeals of adverse determinations made by health maintenance ...
Texas. Legislature. Senate.
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source