Results 71 to 80 of about 752,554 (285)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Enhancing Job Satisfaction Using an Adaptive Neuro-Fuzzy Inference System by Considering HSEE Factors [PDF]

مدیریت مهندسی و رایانش نرم
Job satisfaction plays a crucial role in enhancing productivity and reveals intriguing insights that impact the operational effectiveness of organizations.
Mehrab Tanhaeean, Fatemeh Raeisi, Hamid Saffari   +2 more
doaj   +1 more source

Regulation and the Provision of Quality to Heterogenous Consumers: The Case of Prospective Pricing of Medical Services [PDF]

This gaper analyzes the welfare implications of fixed price regulation in a model in which consumers are heterogeneous and a firm can endogenously quality discriminate.
Paul J. Gertler, Robin Allen
core  

External Program Evaluation: Water, Sanitation and Hygiene (WASH) Program in Ethiopia [PDF]

, 2008
USAID/Ethiopia commissioned this study to evaluate an ongoing Millennium Water Alliance (MWA) program and to generate findings that could assist in developing monitoring and evaluation indicators for future use.
Bruck Aregai, Siseraw Dinku
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Factors associated with the non-retention of health sector employees recruited in Iran: a survival analysis

BMC Health Services Research
Background Health staff are an essential component of the health system and a significant factor in improving health outcomes. As a result, without a suitable number of trained and supported workforces, health-related goals will not be achieved.
Behrooz Rahimi, Faeze Ghasemi Seproo, Roghayeh Khalilnezhad, Mahmoud Khodadost, Tahereh Kashkalani, Fatemeh Younesi, Behzad Tadayon, Mahmood Samadpour, Mahboubeh Bayat   +8 more
doaj   +1 more source

Shelter Development Through Cooperatives: A Strategy for Poverty Alleviation and Slum Improvement for Asia and the Pacific Region [PDF]

, 2002
The research traces the flow of humanity from the urban areas to the cities thus creating severe economic and social problems in the cities thus leading to homelessness; lack of sanitation; health hazards; crimes; vandalism; drugs; children wandering ...
M. L. Khurana
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Bilingual Proficiency Among California's Health Care Professionals [PDF]

, 2005
Explores the policy options for encouraging and measuring second-language competence among healthcare providers in ...
Catherine Dower
core  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source