Results 151 to 160 of about 1,861,055 (314)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Third Annual National Conference on Health Marketing, Communication, and Media : 2009 : Participation, powers, prevention

On behalf of the Centers for Disease Control and Prevention (CDC) and our conference cosponsors\u2014the Substance Abuse and Mental Health Services Administration (SAMHSA), the National Cancer Institute (NCI), and the National Public Health Information ...

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Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Media access guide : a resource for community health promotion [PDF]

March 2008; Updated April 2009CDC\ue2\u20ac\u2122s Healthy Communities Program.We all want to gain access to the media, but how do we obtain the coverage and platforms needed to promote our message and shape public opinion?

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Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Assessing exposure to Kilkari: a big data analysis of a large maternal mobile messaging service across 13 states in India

BMJ Global Health, 2021
Nicki Tiffin, Rajani Ved, Amnesty Elizabeth LeFevre, Kerry Scott, Smisha Agarwal, Nicola Mulder, Neha Shah, Jean Juste Harrisson Bashingwa, Diwakar Mohan, Simone Honikman, Sara Chamberlain, Salil Arora, Jai Mendiratta, Sai Rahul, Vinod Chauhan, Osama Ummer, Jean JH Bashingwa, Aarushi Bhatanagar, Rakesh Chandra, Arpita Chakraborty, Neha Dumke, Priyanka Dutt, Anna Godfrey, Suresh Gopalakrishnan, Nayan Kumar, Amnesty LeFevre, Molly Miller, Radharani Mitra, Deshen Moodley, Angela Ng, Dilip Parida, Nehru Penugonda, Shiv Rajput, Aashaka Shinde, Aaditya Singh, Falyn Weiss, Sonia Whitehead   +36 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Communications guide for state oral health programs: media outreach materials [PDF]

I. Press releases -- II. Media alerts -- III. Fact sheets -- IV. Talking points -- V. Press kits"April 2006."Available via the World Wide Web as an Acrobat .pdf file (143 KB, 15 p.).Support for this project is provided by Cooperative Agreement # 04135 ...
Oral Health America (Consortium)
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Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source