Results 101 to 110 of about 706,349 (318)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Sociodemographic and Health Profile of the Elderly in the city of João Pessoa – PB [PDF]

open access: yesRevista Brasileira em Promoção da Saúde, 2012
Objective: To explore the sociodemographic profile and physical health of elderly enrolled in Family Health Units (USF) in the city of João Pessoa – PB, Brazil, and the factors associated with self-reported diagnoses in this population.
Laryssa Dantas Dias   +4 more
doaj  

Use of Medicines by Community Dwelling Elderly in Ontario [PDF]

open access: yes
OBJECTIVE: Prescription medicine use by the elderly is of growing concern as indicated by a large literature focused on rising costs, patient compliance and the appropriateness of use.
Peri J. Ballantyne   +3 more
core  

Institutionalisation and Quality of Life for Elderly People in Finland. ENEPRI Research Report No. 92, August 2011 [PDF]

open access: yes, 2011
In this paper we examine whether there are systematic differences between the quality of life of an individual who is institutionalised and one who is not, keeping health status and income level constant.
Johansson, Edvard.   +2 more
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Use of Health and Nursing Care by the Elderly. ENEPRI Research Report No. 2, 1 July 2004 [PDF]

open access: yes, 2004
If the hypothesis that people live longer and in better health is true, it could be expected that the changes in the health of the elderly have important consequences for the further demand for health services, the need for long-term care and also for ...
Schulz, Erika.
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

“BUILDING TIES”: USE OF DIALOGUE IN PROMOTING HEALTH OF THE ELDERLY [PDF]

open access: yesRevista Gestão & Saúde, 2014
This paper aims to describe educational activities, developed with a group of the elderly in the city of Itaporanga-PB. These activities relate to the practice of health education for discussion of hypertension and diabetes, constituted by professionals ...
Alessandra Aniceto Ferreira de Figueirêdo   +1 more
doaj  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

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