Results 51 to 60 of about 706,349 (318)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Acta Scientiarum. Health Sciences, 2013 The objective of the study was to analyze the age marker in males and females as a predictor of the absence of frailty syndrome in the elderly. This was a cross-sectional study with 624 individuals.
Sheilla Tribess +5 more
doaj +1 more source
Rethinking care for the sick elderly [PDF]
, 2003 It is well established that Geriatrics and Gerontology are specialties in their own right meriting separate tertiary and primary care training.1 Health Care for the elderly also forms a newly added subject to the field of biomedical ethics.2 Demographic ...
Mallia, Pierre, Fiorini, Anthony
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The organisation of formal long-term care for the elderly. Results from the 21 European country studies in the ANCIEN project. ENEPRI Research Report No. 95, November 2011 [PDF]
, 2011 This report investigates the organisation and provision of long-term care for the elderly population in 21 member states of the European Union, thus including both old as well as new member states.
Kraus, Markus, Riedel, Monika
core
Safeguarding the Right to Health of the Elderly in Rural China: A Legal Analysis
, 2023 Qiang Chen,1 Wei Tian,2 Long Zheng,3 Taoying Li1,4 1Law School, Xinjiang University, Urumqi, People’s Republic of China; 2Department of Foreign Languages, Guangxi Science & Technology Normal University, Laibin, People’s Republic of China; 3Graduate ...
Chen Q, Tian W, Li T, Zheng L
core
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Gender differences in health-related quality of life among the elderly in Taiwan [PDF]
, 2012 [[abstract]]"Purpose: This study examines the gender disparity in the elderly’s health-related quality of life in Taiwan. Method: Data came from the National Health Interview Survey, a series of nation-representative face-to-face interviews held in ...
Hsu), 徐慧娟(Hui-Chuan
core
Home Help Services for Elderly People in Ireland - Conference Proceedings
, 1995 The National Council for the Elderly was established in 1981 as the National Council for the Aged. The terms of reference of the Council are: To advise the Minister for Health on all aspects of ageing and the welfare of the elderly either on its own ...
Department of Health (Ireland)
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source