Results 61 to 70 of about 7,922,717 (359)

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

FEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke, Nils Alexander Lakomek, Georg Groth   +2 more
wiley   +1 more source

[Physical activity, health and health economics].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1980
Ideally this article should begin with a mathematical model--an equation. On the left we should put together contributions and expenditures in terms of hours, money and effort. On the right we should enter the profits in terms of years of life, money and quality of life. Unfortunately it is not that easy.
Waaler, Hans Thomas, Hjort, Peter Fredrik   +1 more
openaire   +3 more sources

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Physics for health

EPS Grand Challenges. Physics for Society in the Horizon 2050; Bristol, UK : IOP Publishing 5 -120 (2024).
Ralph Assmann, Darwin Caldwell, Giulio Cerullo, Henry Chapman, Dana Cialla-May, Marco Durante, Angeles Faus-Golfe, Jens Hellwage, Susanne Hellwage, Christoph Krafft, Timo Mappes, Thomas G Mayerhöfer, Thierry Mora, Andreas Peters, Chiara Poletto, Juergen Popp, Felix Ritort, Petra Rösch, Lucio Rossi, Marta Sales-Pardo, Iwan Schie, Michael Schmitt, Friedrich Simmel, Aleksandra Walczak   +23 more
openaire   +3 more sources

Physical health epidemic in mental health [PDF]

The Psychiatrist, 2013
We would very much welcome the focus on physical health from secondary mental health, as advocated by Bailey et al .[1][1] However, we would like to raise the following points. The Quality Outcomes Framework[2][2] now includes HbA1c levels recorded in the past 15 months to identify diabetes ...
Mukesh Kripalani, Hemagireswari Chaparala   +1 more
openaire   +2 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Optical characteristics of laser medical instrument with side-firing fiber under complete bevel angle range

iScience
Summary: The side-firing instrument is studied under the complete bevel angle range. The fiber core and cladding are 0.6 mm and 0.66 mm, respectively, the fiber core refractive index is 1.457, and the fiber cladding refractive index is from 1.409 to 1 ...
Diqing Ying
doaj   +1 more source

Interactive remote interviews during emergency remote teaching

Physical Review Physics Education Research, 2021
The COVID-19 pandemic has made conducting in-person research a health risk for interviewers and participants. Near the start of the pandemic, many universities pivoted to emergency remote teaching where courses were delivered remotely in observance of ...
Christian D. Solorio, Elizabeth Gire, David Roundy   +2 more
doaj   +1 more source

Physical activity, hydration and health. [PDF]

Nutricion hospitalaria, 2014
1.040 JCR (2014) Q4, 64/77 Nutrition ...
Marcos, Ascensión, Manonelles, Pedro, Palacios, Nieves, Wärnberg, Julia, Casajús Mallén, José Antonio, Pérez Ruiz, Margarita, Aznar Laín, Susana, Benito, Pedro J., Martínez-Gómez, David, Ortega, Francisco B., Ortega, Eduardo, Urrialde, Rafael   +11 more
openaire   +8 more sources

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source