Results 61 to 70 of about 776,447 (351)

Special Issue on Advances in Environmental Applied Physics

Applied Sciences, 2023
This Special Issue, “Advances in Environmental Applied Physics”, is dedicated to collecting original papers from eminent researchers in the field of environmental pollutants, which constitute a health risk to the population, increasing the likelihood of ...
Francesco Caridi
doaj   +1 more source

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

Physical activity and health [PDF]

Nutrition Bulletin, 2007
Summary Introduction Definition and measurement of physical activity Key points Physical activity levels in the UK Key points Physiological effects of physical activity Key points Physical activity in health and disease Key points Physical activity and public health Key points Conclusions Summary  Physical activity levels in the UK are low.
openaire   +5 more sources

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Relationship between science and technology in the New Zealand curriculum [PDF]

, 1997
New Zealand underwent major curriculum reforms in the early1990s. These reforms were determined by the New Zealand Curriculum Framework (Ministry of Education 1993), which provides an overarching framework for the development of curricula in New Zealand ...
Jones, Alister
core   +1 more source

Large publishing consortia produce higher citation impact research but co-author contributions are hard to evaluate [PDF]

, 2019
This paper introduces a simple agglomerative clustering method to identify large publishing consortia with at least 20 authors and 80% shared authorship between articles.
AACR Project GENIE Consortium, Bernstein B. E., Bornmann L., Buniello A., Clifford G. M., Costa M. R., Defazio D., Fortunato S., Garner C., Gene Ontology Consortium, Gibbons M. R., Hagen N. T., Hoekman J., Hu F., Hu F. P., International Human Genome Sequencing Consortium, Ioannidis J. P., Iso H., Kawashima H., Larivière V., Larivière V., Levitt J. M., Liu X. Z., Moed H. F., Mongeon P., Moore F. A., Munafò M. R., Olds J. L., Pe’er I., Psaty B. M., Riedel T., Roberts L., Sjögårde P., Sud P., Thelwall M., Thelwall M., van Raan A., Vermeulen N., Wagner C. S., Waltman L., Waltman L., Welter D., Wu D., Wuchty S., Xie Z.   +44 more
core   +2 more sources

[Physical activity, health and health economics].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1980
Ideally this article should begin with a mathematical model--an equation. On the left we should put together contributions and expenditures in terms of hours, money and effort. On the right we should enter the profits in terms of years of life, money and quality of life. Unfortunately it is not that easy.
Waaler, Hans Thomas, Hjort, Peter Fredrik   +1 more
openaire   +3 more sources

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Physics for health

EPS Grand Challenges. Physics for Society in the Horizon 2050; Bristol, UK : IOP Publishing 5 -120 (2024).
Ralph Assmann, Darwin Caldwell, Giulio Cerullo, Henry Chapman, Dana Cialla-May, Marco Durante, Angeles Faus-Golfe, Jens Hellwage, Susanne Hellwage, Christoph Krafft, Timo Mappes, Thomas G Mayerhöfer, Thierry Mora, Andreas Peters, Chiara Poletto, Juergen Popp, Felix Ritort, Petra Rösch, Lucio Rossi, Marta Sales-Pardo, Iwan Schie, Michael Schmitt, Friedrich Simmel, Aleksandra Walczak   +23 more
openaire   +3 more sources

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source