Results 181 to 190 of about 1,032,633 (361)

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Plastic Surgical Outreach to Low- and Middle-income Countries and Global Health Priorities: An Analysis of 96 Nongovernmental Organizations. [PDF]

Plast Reconstr Surg Glob Open, 2023
Yan A, Castellanos SL, Chao AH.
europepmc   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Towards renewed commitment to prevent maternal mortality and morbidity: learning from 30 years of maternal health priorities. [PDF]

Sex Reprod Health Matters, 2023
Solnes Miltenburg A, Kvernflaten B, Meguid T, Sundby J.   +3 more
europepmc   +1 more source

Priority setting in health care [PDF]

, 2000
Richard Cookson
openalex   +1 more source

The moral relevance of personal characteristics in setting health care priorities [PDF]

This paper discusses the moral relevance of accounting for various personal characteristics when prioritising between groups of patients. After a review of the results from empirical studies, we discuss the ethical reasons which might explain – and ...
Dolan, Paul, Mentzel, Paul, Olsen, Jan Abel, Ricardson, Jeff   +3 more
core  

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

Molecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche, Renske Imschoot, Béatrice Lintermans, Lode Denolf, Joachim Taminau, Charlotte Fieuws, Geert Berx, Kris Gevaert, Kathleen B. M. Claes   +8 more
wiley   +1 more source

COVID-19-related global health governance and population health priorities for health equity in G20 countries: a scoping review. [PDF]

Int J Equity Health, 2023
Mac-Seing M, Gidey M, Di Ruggiero E.
europepmc   +1 more source

EPA priorities for biologic markers research in environmental health.

, 1992
John R. Fowle, K. Sexton
openalex   +1 more source

Priority setting for health research: lessons from developing countries [PDF]

, 2000
The Working Group on Priority Setting
openalex   +1 more source