Results 101 to 110 of about 65,601,074 (263)
Irish Health Research Forum meeting. Theme: should Ireland set health research priorities? [PDF]
, 2018 This report presents the proceedings of the Irish Health Research Forum on May 21st, 2018 focusing on the topic of whether Ireland should set health research ...
Medical Research Charities Group
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From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
HRB Strategic Business Plan 2010 – 2014: The future of Irish health research
, 2009 The new Health Research Board (HRB) strategic business 2010 – 2014 plan will focus on improving people’s health, transforming our health services and supporting new enterprise and the economy over the next five years. A shift in focus will see the HRB
Health Research Board
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Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Health Research Board Annual Report Part 2: Corporate Governance 2022 and Financial Statements [PDF]
Te Board of the Health Research Board (HRB) was established under Te Health Research Board (Establishment) Order 1986 (S.I. NO.279 of 1986) as amended. Te functions of the HRB are set out in Article 4 of this statutory instrument.
Health Research Board
core
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Response to Sinn Féin Priorities for Change in Health & Social Care, 2023 [PDF]
We welcome the very considered priorities for change in health and social care that have been put together by Sinn Féin. Below are some suggestions to add to or modify those priorities.
Health Research Charities Ireland
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source