Results 201 to 210 of about 4,046,896 (267)

Organ-Specific Accumulation and Health Risk Assessment of Aliphatic and Polycyclic Aromatic Hydrocarbons in Tilapia zillii. [PDF]

Environ Anal Health Toxicol
Ifeanyi Kenneth A, Agboeze E, Udeozo PI, Ofordile VA, Agboeze HO.   +4 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Post-seismic indoor radon exposure in ground-floor gyms: amplified health risk during physical exercise. [PDF]

Front Public Health
Baler S, Ozdurak Singin RH, Denizci T, Agascioglu EA.   +3 more
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Temporal Reproducibility of a Genetic Algorithm-Derived Health Risk Score: Standardized Out-of-Fold Validation Framework (2021-2023). [PDF]

JMIR Bioinform Biotechnol
Aoki Y, Takeda H, Yokota K, Yoshida R.
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Spatiotemporal Dynamics and Human Health Risk Assessment of Potentially Toxic Elements in Global Urban Soils: A Systematic Meta-Analysis. [PDF]

Toxics
Cui J, Lu J, Lai Y, Wei Q, Zhao X.
europepmc   +1 more source

Redefining the Health Risk of Battery Materials Through a Biologically Transformed Metal Mixture. [PDF]

Adv Sci (Weinh)
Zhang Z, Miao G, Zhang X, Shu Z, Lu D, Song Y, Yu S, Liu Q, Song Y, Zhang R, Jin X, Zheng Y.   +11 more
europepmc   +1 more source

Directions and Perspectives for Preventive Activities in Primary Care-Patients' Health-Promoting and Health-Risk Behaviours. [PDF]

Nutrients
Domańska A, Lachowicz-Wiśniewska S, Żukiewicz-Sobczak W.   +2 more
europepmc   +1 more source