Results 231 to 240 of about 8,841,875 (314)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Magnesium Depletion Score as an Indicator of Health Risk and Nutritional Status-A Scoping Review. [PDF]

Nutrients
Costello RB, Fan Z, Wallace TC.
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

The impact of a growth mindset on adolescents' health risk behaviors: the chain mediating role of core self-evaluation and coping style. [PDF]

BMC Psychol
Xu X, Ding Y, Zhang Y, Xu M, Huang Y, Chang S, Xin S.   +6 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Phthalate exposure and its impact on mental health risk in the elderly Thai population. [PDF]

Discov Ment Health
Kaewboonchoo O, Bhrasartsuwan M, Tantrakarnapa K, Ekpanyaskul C.   +3 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Human brucellosis in pregnancy in western Uganda: High seroprevalence and health risk factors identified in a cross-sectional study. [PDF]

PLoS Negl Trop Dis
Virginia W, Ishimwe MPS, Kazigo AK, Tshilumba T, Rukamba JD, Pius T, Isse SAS, Hakizimana T.   +7 more
europepmc   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Human Exposure to Metals and Potential Human Health Risk in a Volcanic Environment in Italy. [PDF]

Toxics
Forte G, Rapisarda V, Ruggieri F, Battistini B, Bauleo L, Filetti V, Grignani E, Lovreglio P, Matera S, Senia P, Vella F, Vitale E, Bocca B, Iavicoli I.   +13 more
europepmc   +1 more source