Results 131 to 140 of about 4,533,217 (309)

A co-created citizen science project on the short term effects of outdoor residential woodsmoke on the respiratory health of adults in the Netherlands

Environmental Health
Background and aim Woodsmoke from household fireplaces contributes significantly to outdoor air pollution in the Netherlands. The current understanding of the respiratory health effects of exposure to smoke from residential wood burning is limited.
Frederique Froeling, Jie Chen, Kees Meliefste, Marieke Oldenwening, Esther Lenssen, Roel Vermeulen, Miriam Gerlofs-Nijland, Jos van Triel, Amber Woutersen, Dave de Jonge, Henke Groenwold, Paula Bronsveld, Danielle van Dinther, Marcus Blom, CHARRED Citizen Scientists, Gerard Hoek   +15 more
doaj   +1 more source

Analysis of nuclear waste disposal in space, phase 3. Volume 1: Executive summary of technical report [PDF]

The objectives, approach, assumptions, and limitations of a study of nuclear waste disposal in space are discussed with emphasis on the following: (1) payload characterization; (2) safety assessment; (3) health effects assessment; (4) long-term risk ...
Friedlander, A. L., Martin, W. E., Miller, N. E., Rice, E. E., Yates, K. R.   +4 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Association of IL-8 and CXCR2 with AST/ALT Ratio in Liver Abnormalities Screening during Oxidative Stress Injury Caused by VCM

Journal of Toxicology
Liver impairment caused by VCM has been linked to irreversible damage such as fibrosis, necrosis, hepatocellular carcinoma, and liver angiosarcoma. However, the ability to detect abnormalities during initial phase have not been achieved so far.
Yiwen Dong, Xingang Wang, Weijiang Hu, Xin Wang, Hongying Bian, Wencui Zhang, null Feng Han, Ning Kang, Lin Zhang, Meng Ye   +9 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Analysis of selected organochlorine pesticides in honey samples from Poland: a pilot study

Roczniki Panstwowego Zakladu Higieny
Background Organochlorine pesticides (OCPs) were widely used in crop protection in the past. Due to their high chemical persistence and widespread presence in the environment, they have been classified as persistent organic pollutants (POPs). Given their
Radosław Lewiński, Agnieszka Hernik, Monika Liszewska, Katarzyna Czaja, Wojciech Korcz, Paweł Struciński   +5 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

A Study for the Necessity of Risk Assessment for Heavy metal Pollution in the Barada Basin, Syria [PDF]

Manufacturing industries are blooming rapidly in Barada Basin carrying high risk to environment and human health due to generating huge amounts of heavy metals to environmental media, particularly rivers. Few studies show that concentrations of chromium,
Rimah Melhem, Yoshiro Higano
core  

Laboratory Focus on Improving the Culture of Biosafety: Statewide Risk Assessment of Clinical Laboratories That Process Specimens for Microbiologic Analysis [PDF]

, 2018
The Wisconsin State Laboratory of Hygiene challenged Wisconsin laboratories to examine their biosafety practices and improve their culture of biosafety.
Batemman, Allen C., Beck, eric, Block, Timothy K., Bowles, Erin J., Dern, Richard, Kropp, Joshua L., Munson, Erik, Podzorski, Raymond P., Radke, Tyler, Siebers, Karen, Simmons, Brian, Smith, Mary A., Spray-Larson, Frances, Warshauer, David M.   +13 more
core   +1 more source