Results 111 to 120 of about 13,472,376 (354)

Serial amplification of tau filaments using Alzheimer's brain homogenates and C322A or C322S recombinant tau

FEBS Letters, EarlyView.
We investigated the seeded assembly of 0N3R tau and two variants, C322A and C322S, designed to model the mutation landscape at residue 322, using Alzheimer's disease brain homogenates in a real‐time quaking‐induced conversion (RT‐QuIC) assay. The C322A variant formed filaments that partially resembled the paired helical filament (PHF) structure ...
Alessia Santambrogio, Sofia Lövestam, Michael A. Metrick II, Thomas Löhr, Peifeng Xu, Nicholas C. T. Gallagher, Bernardino Ghetti, Byron Caughey, Sjors H. W. Scheres, Michele Vendruscolo   +9 more
wiley   +1 more source

Primary tumor resection in de novo metastatic breast cancer from an oligometastatic perspective: A systematic review and meta-analysis

iScience
Summary: Whether patients with de novo metastatic breast cancer (de novo MBC) benefit from primary tumor resection (PTR) is controversial, and the efficacy of treatment of primary tumor in patients with oligometastases is uncertain.
Chen Wu, Xiang Li, Shiyang Liu, Litong Yao, Tianyi He, Yusong Wang, Haoran Dong, Shuyi Niu, Mozhi Wang, Yingying Xu   +9 more
doaj   +1 more source

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

FEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

Single cis‐elements in brassinosteroid‐induced upregulated genes are insufficient to recruit both redox states of the BIL1/BZR1 DNA‐binding domain

FEBS Letters, EarlyView.
Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki, Masae Ohtsuka, Takeshi Nakano, Masaru Tanokura, Takuya Miyakawa   +4 more
wiley   +1 more source

ACSS2 involved in acetyl‐CoA synthesis regulates skeletal muscle function

FEBS Letters, EarlyView.
The enzyme acyl‐coenzyme A synthetase short‐chain family member‐2 (ACSS2) catalyzes the conversion of acetate to acetyl‐CoA, but its function in skeletal muscle is unclear. We studied ACSS2 deficiency in mouse and fly models. Skeletal muscle from the mouse model showed atrophic fibers, excess lipid, and depleted NADH.
Mekala Gunasekaran, Gloriana Campos, Natalya M. Wells, Khanhlinh Lambuu, Isabelle Draper, Christina A. Pacak, Peter B. Kang   +6 more
wiley   +1 more source

Health sciences tutors

Revista de la Facultad de Ciencias de la Salud, 2012
It seems obvious, but for teaching in health sciences faculties, it is not enough to be a doctor or specialist. In fact, “medical education” is taught as a specialty in many universities of the country.
Mario Delgado-Noguera
doaj  

Drug nanocrystals: Surface engineering and its applications in targeted delivery

iScience
Summary: Drug nanocrystals have received significant attention in drug development due to their enhanced dissolution rate and improved water solubility, making them effective in overcoming issues related to drug hydrophobicity, thereby improving drug ...
Phattalapol Lhaglham, Luksika Jiramonai, Yaru Jia, Baoying Huang, Yuanyu Huang, Xueyun Gao, Jinchao Zhang, Xing-Jie Liang, Mengliang Zhu   +8 more
doaj   +1 more source

Minimally invasive versus conventional mitral valve surgery: a propensity-matched comparison.

Journal of Thoracic and Cardiovascular Surgery, 2010
L. Svensson, F. Atik, D. Cosgrove, E. Blackstone, J. Rajeswaran, G. Krishnaswamy, Ung Jin, A. Gillinov, B. Griffin, J. Navia, T. Mihaljevic, B. Lytle, Health Sciences   +12 more
semanticscholar   +1 more source

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

FEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke, Nils Alexander Lakomek, Georg Groth   +2 more
wiley   +1 more source

Cilia, Ciliated Epithelium and Ciliary Activity . Volume 15 of International Series of Monographs on Pure and Applied Biology–Modern Trends in Physiological Sciences. BY JOSÉ A. RIVERA, Naval Biological Laboratory of the School of Public Health, University of California, Berkeley. Cloth.$9.50. Pp. 167, with 19 illustrations. Pergamon Press, New York, Oxford, London, Paris, 1962 [PDF]

, 1962
M. DIGBY LEIGH
openalex   +1 more source