Results 71 to 80 of about 1,816,296 (269)

Linear and non-linear associations of depressive symptoms with oral health knowledge, attitudes, and practices among rural older adults in China: a cross-sectional study

BMC Public Health
Background Depression affects the oral health of older adults; however, little is known about its impact on oral health among rural older adults in developing countries, which warrants further research.
Wenwen Cao, Chenglin Cao, Ying Guo, Zixuan Hong, Xin Zheng, Bohua Ren, Zhi Hu, Ren Chen, Zhongliang Bai   +8 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Real-world impact of physical activity reward-driven digital app use on cardiometabolic and cardiovascular disease incidence

Communications Medicine
Background The lack of effective tools available to health providers for enhancing patient physical activity prompts this study to examine the real-world impact of a physical activity reward-driven app on health outcomes, utilizing Electronic Health ...
Adi Berliner Senderey, Tom Mushkat, Ofer Hadass, Daphna Carmeli, Samah Hayek, Marie-Laura Charpingnon, Eyal Jacobson, Ran D. Balicer   +7 more
doaj   +1 more source

Analysis and Suggestions on the Current Situation of Mental Health Education and Social Psychological Service System in Ethnic Areas [PDF]

, 2021
Bei Song, Guipin Que
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Geno4ME Study: implementation of whole genome sequencing for population screening in a large healthcare system

npj Genomic Medicine
The Genomic Medicine for Everyone (Geno4ME) study was established across the seven-state Providence Health system to enable genomics research and genome-guided care across patients’ lifetimes. We included multi-lingual outreach to underrepresented groups,
Isabelle A. Lucas Beckett, Kate R. Emery, Josiah T. Wagner, Kathleen Jade, Benjamin A. Cosgrove, John Welle, JB Rinaldi, Lindsay Dickey, Kyle Jones, Nick Wagner, Eric M. Shull, Jon Clemens, Kalliopi Trachana, Lance Anderson, Allison Kudla, Brett Smith, Hakon Verespej, Li Chi Yuan, Elizabeth Denne, Erica Ramos, Jennifer C. Lovejoy, Krzysztof Olszewski, Martin G. Reese, Misty J. Reynolds, Mandy M. Miller, Alexa K. Dowdell, Brianna Beck, James M. Scanlan, Mary B. Campbell, Andrew T. Magis, Keri Vartanian, Brian D. Piening, Carlo B. Bifulco, Ora K. Gordon   +33 more
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Identifying Higher-Volume Antibiotic Outpatient Prescribers Using Medicare Part D Prescription Data — Arizona, 2021

Antimicrobial Stewardship & Healthcare Epidemiology
Background: Increased antibiotic resistance is a rising global health problem that can result from overprescribing and misusing antibiotics. The impact of antibiotic overprescribing is significant, particularly among the older adult population due to ...
Swathi Vajrala, Rachana Bhattarai, Tho Pham, Mandana Naderi, Celine Sanchez, Elizabeth Kim, Kenneth Komatsu   +6 more
doaj   +1 more source