Results 71 to 80 of about 5,632,643 (360)

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

Development of the Tiers of Service framework to support system and operational planning for children’s healthcare services

BMC Health Services Research, 2021
Background Providing access to pediatric healthcare services in British Columbia, Canada, presents unique challenges given low population densities spread across large geographic distances combined with a lack of availability of specialist providers in ...
Sina Waibel, Janet Williams, Yasmin Tuff, Joanne Shum, Jennifer Scarr, Maureen O’Donnell   +5 more
doaj   +1 more source

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

Quality criteria for young people friendly health services [PDF]

, 2011
The Department of Health ‘Quality criteria for young people friendly health services’, which is referred to as ‘You’re Welcome’, sets out principles to help commissioners a nd service providers to improve the suitability of NHS and non-NHS health ...

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Low-Dose Clozapine Reduces Aggression in Violent Substance Use Disorder Patients at a Secure Rehabilitation Center

Case Reports in Psychiatry
Managing aggressive behaviors in patients with substance use disorders (SUDs), particularly when accompanied by comorbid psychiatric disorders, presents considerable challenges.
Suhair Mohammed Yousuf, Abdelrahman Zohir Khaled Eldous, Faycal Walid Ikhlef, Nirvana Swamy Kudlur Chandrappa, Majid Ali Y. A. Al Abdulla   +4 more
doaj   +1 more source

Case validation of bloodstream infections with an antibiotic-resistant organism

Antimicrobial Stewardship & Healthcare Epidemiology
Background: Bloodstream infections (BSIs) are an important cause of morbidity and mortality in severely ill patients, contributing to increased length of hospital stay and higher cost of care. Alberta Health Services Infection Prevention and Control (IPC)
Jennifer Ellison, Blanda Chow, Andrea Howatt, Logan Armstrong, Ted Pfister, Zhe Lu, Kathryn Bush   +6 more
doaj   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

Tanzania: In their own words: Poor women and health services. [PDF]

, 2004
"In Their Own Words: Poor Women And Health Services" highlights critical constraints that poor women experience in accessing health services, including the challenges they face and the strategies they use to overcome them. This summary report is meant to
Women's Dignity Project/Utu Mwanamke, (WDP)
core  

Timely data on the dynamic drug supply is crucial in addressing the ongoing drug poisoning crisis. The team is exploring ways to share information with emergency responders, healthcare providers, government officials, and pwSUD.

International Journal of Population Data Science
Objective Transitioning from hospitals to primary care brings significant challenges, including increased readmission rates, mortality, and costs due to information gaps.
Tanmay Patil, Robin Walker, Congshi Shi, Wanning Song, Judy Seidel, Scott Oddie   +5 more
doaj   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source