By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Evaluation of the quality of Primary Health Care services for children : reflections on the feasibility of using the Brazilian version of the Primary Care Assessment Tool as a routine assessment tool [PDF]
Objective To assess the quality of the Primary Health Care services provided to children and the feasibility of using the Brazilian version of Primary Care Assessment Tool (PCAT-Brazil) as a routine quality assessment tool.
Demarzo, Marcelo +6 more
core +2 more sources
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
SPATIAL ACCESSIBILITY OF HEALTH CARE IN INDIANA [PDF]
Healthy populations and access to health care services are significant factors influencing economic development and prosperity. Since geographic access is an essential feature of an overall health system, it is important for health service researchers to
Brigitte S. WALDORF +2 more
core
Listen up: Reflections on the CDI and HSE Speech and Language Services in Tallaght West [PDF]
The primary aim of this study was to build on the previous evaluation of the Childhood Development's Initiatives (CDI) speech and language approach and carry out a comparative evaluation of speech and language therapy services for young children across ...
Judy Irwin, Nóirín Hayes
core
Immigration Policy and Access to Health Services [PDF]
Section 287(g) of the Immigration and Nationality Act (INA), added in 1996, authorizes the U.S. Immigration and Custom Enforcement (ICE) to enter into agreements with state and local law enforcement agencies to enforce federal immigration law during their regular, daily law-enforcement activity (www.ice.gov/287g). The original intent was to “target and
openaire +2 more sources
Cell wall target fragment discovery using a low‐cost, minimal fragment library
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
IntroductionInequities in accessibility to, and utilisation of maternal healthcare services impede progress towards attainment of the maternal health-related Millennium Development Goals.
J. Ganle +3 more
semanticscholar +1 more source
Cultural matter in the development of an interactive multimedia self-paced educational health program for aboriginal health workers [PDF]
Aboriginal and Torres Strait islander health workers are key providers of primary health services to Aboriginal communities especially in remote and rural areas. They are often overloaded with competing demands.
El Sayed, Faeka +2 more
core

