Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Utilization of dental services by preschool children: prevalence and associated factors [PDF]
Brazilian Oral ResearchDental associations worldwide recommend that the first dental visit should take place before 12 months of age; however, preschoolers’ utilization of dental services remains low.
Isabela da Costa GONÇALVES +6 more
doaj +1 more source
Regulation versus practice - The impact of accessibility on the use of specialist health care in Norway [PDF]
In Norway specialized health services are provided both by public hospitals and by privately practicing specialists who have a contract with the public sector. Patients’ co-payment is the same irrespective of the type of provider they visit. The ambition
Iversen, Tor, Kopperud, Gry Stine
core
The Right to Mental Health in the Digital Era [PDF]
, 2016 People with mental illness usually experience higher rates of disability and mortality. Often, health care systems do not adequately respond to the burden of mental disorders worldwide.
Bakx, I. (Iris) +2 more
core +4 more sources
Occupational health: Accessing services [PDF]
British Dental Journal, 2017 R, McMullan, B, Hendron, M, Donaldson
openaire +2 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Territórios do Sistema Único de Saúde: mapeamento das redes de atenção hospitalar
Cadernos de Saúde PúblicaEste trabalho investiga dois tipos de redes estabelecidas pelos fluxos de pacientes para os serviços de saúde: a de atenção hospitalar básica, definida pelos procedimentos com maior freqüência de internação e as de atenção de alta complexidade. Agregaram-
Evangelina X. G. de Oliveira +2 more
doaj
Accessibility to health services in the prison population in Colombia: a public health challenge
Revista Facultad Nacional de Salud Pública, 2010 This article is the result of a product of a study elaborated with the aim of systematizing the available information related to the accessibility to the health services of the prison population in the penitentiary centers.
Luz Mery Mejía O, Jeniffer Hernández P
doaj
Access to Oral Health Actions According to Social and Individual Determinants
Pesquisa Brasileira em Odontopediatria e Clínica Integrada, 2022 Objective: To investigate the socioeconomic, demographic and health needs that influence the access to oral health actions. Material and Methods: The sample consisted of 609 individuals who lived in areas covered by the Family Health Strategy in a city ...
Deborah Ellen Wanderley Gomes Freire +9 more
doaj
Assessing preventable hospitalisation indicators (APHID): protocol for a data-linkage study using cohort study and administrative data [PDF]
, 2012 Introduction Potentially preventable hospitalisation (PPH) has been adopted widely by international health systems as an indicator of the accessibility and overall effectiveness of primary care. The Assessing Preventable Hospitalisation InDicators (APHID)
Blyth, F.M. +5 more
core +2 more sources