Results 61 to 70 of about 225,238 (310)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Psychological well-being among US adults with arthritis and the unmet need for mental health care

Open Access Rheumatology: Research and Reviews, 2017
Laura E Straub,1,2 Miriam G Cisternas3 1Emory University, Atlanta, GA, 2Immune Tolerance Network, San Francisco, CA, 3MGC Data Services, Carlsbad, CA, USA Purpose: Mental health conditions can increase the risk of disability among adults with arthritis ...
Straub LE, Cisternas MG
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KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Access to Oral Health Actions According to Social and Individual Determinants

Pesquisa Brasileira em Odontopediatria e Clínica Integrada, 2022
Objective: To investigate the socioeconomic, demographic and health needs that influence the access to oral health actions. Material and Methods: The sample consisted of 609 individuals who lived in areas covered by the Family Health Strategy in a city ...
Deborah Ellen Wanderley Gomes Freire, Renata de Souza Coelho Soares, Renata Cardoso Rocha Madruga, Antares Silveira Santos, Vanessa Alves de Medeiros, Allyson Martim Medeiros Lira, Anny Mirene Alves Moreira Rodrigues, Ítalo de Macedo Bernadino, Andreia Medeiros Rodrigues Cardoso, Alessandro Leite Cavalcanti   +9 more
doaj  

Utilization of dental services by preschool children: prevalence and associated factors [PDF]

Brazilian Oral Research
Dental associations worldwide recommend that the first dental visit should take place before 12 months of age; however, preschoolers’ utilization of dental services remains low.
Isabela da Costa GONÇALVES, Valéria Silveira COELHO, Joana RAMOS-JORGE, Priscila Seixas MOURÃO, Kaio Henrique SOARES, Maria Letícia RAMOS-JORGE, Izabella Barbosa FERNANDES   +6 more
doaj   +1 more source

Availability and accessibility of primary mental health services for adolescents:an overview of national recommendations and services in EU [PDF]

, 2020
BACKGROUND: Mental health problems in adolescence can profoundly jeopardize adolescent current and future health and functioning. We aimed to describe existing recommendations and services regarding the delivery of primary mental health care for ...
Visser, Annemieke; id_orcid, Michaud, Pierre André, Visser, A., Kocken, Paul; id_orcid, Michaud, PA, Kocken, Paul, Vervoort, Johanna P.M., Michaud, Pierre-André, Visser, Annemieke, Vervoort, JPM, Reijneveld, Sijmen A, Reijneveld, Sijmen A; id_orcid, Reijneveld, S.A., Jansen, Danielle E M C, Reijneveld, S A, Jansen, Danielle E.M.C., Jansen, DEMC, Reijneveld, Sijmen A., Kocken, P., Vervoort, Johanna P M, Michaud, P.A.   +20 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Use of Health Care Services and Associated Factors among Women.

Iranian Journal of Public Health, 2014
To estimate the prevalence and analyze factors associated with both public and private health services utilization in women population in a western district of Iran.A cross-sectional study with 1200 individuals aged 18-49 years carried out in different ...
Nader Esmailnasab, Jafar Hassanzadeh, Shahab Rezaeian, Mehrdad Barkhordari   +3 more
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Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Accessibility to health services in the prison population in Colombia: a public health challenge

Revista Facultad Nacional de Salud Pública, 2010
This article is the result of a product of a study elaborated with the aim of systematizing the available information related to the accessibility to the health services of the prison population in the penitentiary centers.
Luz Mery Mejía O, Jeniffer Hernández P
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