Results 91 to 100 of about 225,565 (218)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Fatores condicionantes para o acesso às equipes da Estratégia Saúde da Família no Brasil

Saúde em Debate
O artigo analisa o acesso às equipes certificadas pelo Programa Nacional de Melhoria de Acesso e da Qualidade da Atenção Básica, tendo por categoria central o acesso potencial e duas dimensões: acolhimento e disponibilidade.
Márcia Guimarães de Mello Alves, Elisete Casotti, Luisa Gonçalves Dutra de Oliveira, Mônica Tereza Christa Machado, Patty Fidelis de Almeida, Marcos Paulo Fonseca Corvino, Juliana Marin, Regina Fernandes Flauzino, Luiz Albérico Araújo Montenegro   +8 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

How accessible are the websites of health services for people who have had a stroke?

International Journal for Equity in Health
Background After sudden onset conditions (e.g., stroke), people commonly search for information online about healthcare and health services. Accessible websites are important for people with support needs, such as aphasia, to maximise their access to ...
Melita J. Giummarra, Eleanor Brown, Tanya A. Rose, Natasha A. Lannin, Brooke Parsons, Emma Power, On behalf of the Young Stroke Service team   +6 more
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Perceptions of public and private health services in Poland: findings from a 2025 nationwide survey

BMC Health Services Research
Background Healthcare systems worldwide operate through diverse models of service delivery, with public and private sectors playing distinct yet often complementary roles in ensuring access to care.
Agata Olearczyk, Kuba Sękowski, Mateusz Jankowski, Agnieszka Kamińska, Piotr Winciunas, Justyna Grudziąż-Sękowska   +5 more
doaj   +1 more source

Influence of multiprofessional work on the production of care and access to primary health care

Revista CEFAC
Objective: to analyze how the work of four family health teams, in Brazilian Midwest and South regions, influences the capacity of the services in guaranteeing access. Methods: this is a descriptive study with a qualitative approach.
Erica Lima Costa de Menezes, Magda Duarte dos Anjos Scherer, Flávia Regina Souza Ramos   +2 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source