Results 131 to 140 of about 1,907,749 (393)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Improving the accessibility of health services in urban and regional settings for Indigenous people [PDF]
Introduction: Even though a wide range of health services exist in most urban and regional centres, they are not necessarily accessible. Accessible health services are physically accessible, affordable, appropriate and acceptable (that is, culturally ...
core
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Psychological well-being among US adults with arthritis and the unmet need for mental health care
Open Access Rheumatology: Research and Reviews, 2017 Laura E Straub,1,2 Miriam G Cisternas3 1Emory University, Atlanta, GA, 2Immune Tolerance Network, San Francisco, CA, 3MGC Data Services, Carlsbad, CA, USA Purpose: Mental health conditions can increase the risk of disability among adults with arthritis ...
Straub LE, Cisternas MG
doaj
Aksesibilitas Menuju Fasilitas Kesehatan Di Kota Bandung [PDF]
, 2013 Accessibility influences people's chance to reach health facilities. The purposes of this study are to analyze the accessibility to reach health facilities and to compare the accessibility for different classes of health facilities in Bandung.
Hadi, P. L. (Prayoga) +2 more
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Elderly's accessibility to oral health services: an integrative review
, 2022 Sílvia Carréra Austregésilo +4 more
openalex +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
An Entrepreneurship Model for Energy Empowerment of Indian Households - Economic and Policy Analysis [PDF]
Provision of modern energy services for cooking (gaseous fuels) and lighting (electricity) is an essential component of any policy aiming to address health, education or welfare issues; yet it gets little attention from policymakers.
B. Sudhakara Reddy +2 more
core +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source