Results 141 to 150 of about 746,126 (311)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

How accessible are the websites of health services for people who have had a stroke?

International Journal for Equity in Health
Background After sudden onset conditions (e.g., stroke), people commonly search for information online about healthcare and health services. Accessible websites are important for people with support needs, such as aphasia, to maximise their access to ...
Melita J. Giummarra, Eleanor Brown, Tanya A. Rose, Natasha A. Lannin, Brooke Parsons, Emma Power, On behalf of the Young Stroke Service team   +6 more
doaj   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Fatores condicionantes para o acesso às equipes da Estratégia Saúde da Família no Brasil

Saúde em Debate
O artigo analisa o acesso às equipes certificadas pelo Programa Nacional de Melhoria de Acesso e da Qualidade da Atenção Básica, tendo por categoria central o acesso potencial e duas dimensões: acolhimento e disponibilidade.
Márcia Guimarães de Mello Alves, Elisete Casotti, Luisa Gonçalves Dutra de Oliveira, Mônica Tereza Christa Machado, Patty Fidelis de Almeida, Marcos Paulo Fonseca Corvino, Juliana Marin, Regina Fernandes Flauzino, Luiz Albérico Araújo Montenegro   +8 more
doaj   +1 more source

Animal Health Policy and Practice: Scaling-up Community-based Animal Health Systems, Lessons from Human Health [PDF]

In an extensive literature review, the author develops policy recommendations to facilitate scaling up community-based animal health systems to the national level.
Riviere-Cinnamond, Ana
core   +1 more source

Pharmaceutical Industry\u27s Effect on Socioeconomic Development in Sub-Saharan Africa in Relation to Family Planning Accessibility [PDF]

, 2019
There is a large unmet need for family planning services in sub-Saharan Africa (Goodkind et al, 2018). Pharmaceutical companies contribute to the accessibility of medications in developing countries (Cottingham & Berer, 2011).
Demarest, Tessa
core   +1 more source

[Effective access to health services: operationalizing universal health coverage].

Salud publica de Mexico, 2015
The right to health and its operational form, as an organized social response to health: the right to health protection, are the mainstay for the global push towards universal health coverage. The path to achieve this goal is particular to each country and relates to the baseline and specific context in relation to what is feasible. In practical terms,
Germán Fajardo-Dolci, Juan Pablo Gutiérrez, Sebastián García-Saisó   +2 more
openaire   +2 more sources

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Aksesibilitas Menuju Fasilitas Kesehatan Di Kota Bandung [PDF]

, 2013
Accessibility influences people's chance to reach health facilities. The purposes of this study are to analyze the accessibility to reach health facilities and to compare the accessibility for different classes of health facilities in Bandung.
Hadi, P. L. (Prayoga), Joewono, T. B. (Tri), Santosa, W. (Wimpy)   +2 more
core