Results 131 to 140 of about 746,126 (311)

Place Rank: Valuing Spatial Interactions [PDF]

Accessibility measures the potential of opportunities for interaction. This paper proposes and explores a new flow-based measure, 'place rank' using origin-destination information.
Ahmed El-Geneidy, David Levinson
core  

Health Care Accessibility of Lebanese Working-Age Adults with Musculoskeletal Disability [PDF]

, 2016
Background. The diversity of the Lebanese society increased after the 1975-1990 civil war, the grapes of Wrath conflict and July 2006 war. Musculoskeletal disabilities affect up to 10% of this population.
Chalah, Moussa A., El Bejjani, Lina, Haidar, Mona, Jaber, Amani, Jebai, Ibrahim, Raad, Kareem, Shahine, Hanna   +6 more
core  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

The Bambuí Health and Aging Study (BHAS): factors associated with hospitalization of the elderly

Cadernos de Saúde Pública, 2001
This study aimed to identify factors associated with hospital admissions of the elderly. All residents of Bambuí, Minas Gerais State > or = 60 years (n = 1,742) were selected. Some 1,606 of these (92.2%) participated in the study.
Guerra Henrique L., Firmo Josélia O. A., Uchoa Elizabeth, Lima-Costa Maria Fernanda F.   +3 more
doaj  

Improving spatial accessibility to health care services in Cali, Colombia: stakeholder assessment of an innovative platform

Revista Panamericana de Salud Pública
Objectives. To (i) ascertain stakeholders’ perceptions of the contextual factors and resources necessary to successfully implement the AMORE platform, a tool that provides accessibility assessments for health care services, considering factors such ...
Carmen J. Villamizar Jaimes, Luis Gabriel Cuervo, Eliana Martinez Herrera, Lucinda Cash-Gibson, Ciro Jaramillo, Joan Benach   +5 more
doaj   +1 more source

Have pro-poor health policies improved the targeting of spending and the effective delivery of health care in South Africa? [PDF]

Since 1994 there have been a number of radical changes in the public health care system in South Africa. Budgets have been reallocated, decision making was decentralised, the clinic network was expanded and user fees for primary health care were ...
Christelle Swanepoel, Ronelle Burger
core  

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Dynamic measurements of geographical accessibility considering traffic congestion using open data: a cross-sectional assessment for haemodialysis services in Cali, ColombiaResearch in context

The Lancet Regional Health. Americas
Summary: Background: Many cities with traffic congestion lack accessibility assessments accounting for traffic congestion and equity considerations but have disaggregated georeferenced municipal-level open data on health services, populations, and ...
Luis Gabriel Cuervo, Carmen Juliana Villamizar, Lyda Osorio, María Beatriz Ospina, Diana E. Cuervo, Daniel Cuervo, María O. Bula, Pablo Zapata, Nancy J. Owens, Janet Hatcher-Roberts, Edith Alejandra Martín, Felipe Piquero, Luis Fernando Pinilla, Eliana Martínez-Herrera, Ciro Jaramillo   +14 more
doaj   +1 more source