Results 51 to 60 of about 688,867 (354)

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

Potential Change of Spatial Accessibility to Health Services With the Opening of Private Streets in Shenzhen, China

open access: yesIEEE Access, 2018
The spatial accessibility to urban health services is a key issue for urban environment and public health studies, especially among developing countries with explosive population growth and limited urban land space.
Wenhao Yu   +4 more
doaj   +1 more source

Immigration Policy and Access to Health Services [PDF]

open access: yesJournal of Immigrant and Minority Health, 2013
Section 287(g) of the Immigration and Nationality Act (INA), added in 1996, authorizes the U.S. Immigration and Custom Enforcement (ICE) to enter into agreements with state and local law enforcement agencies to enforce federal immigration law during their regular, daily law-enforcement activity (www.ice.gov/287g). The original intent was to “target and
openaire   +3 more sources

A GIS-based assessment of spatial accessibility to County hospitals: A case study of dancheng County, China [PDF]

open access: yes, 2012
National Science Foundation of China; Shanghai Jiao Tong University; Nanyang Technological UniversityThe aim of this study was to investigate Chinese rural people's accessibility to healthcare.
A. Lovett   +6 more
core   +2 more sources

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

Stakeholder views on publication bias in health services research [PDF]

open access: yes, 2020
Objectives: While the presence of publication bias in clinical research is well documented, little is known about its role in the reporting of health services research.
Ayorinde, Abimbola A   +6 more
core   +3 more sources

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

ADDRESSING GAPS IN THE DELIVERY OF COMMUNITY SERVICES: THE CASE OF ONE INNER-CITY COMMUNITY [PDF]

open access: yes, 1981
The need for more effective approaches to the delivery of health and social services in inner-city communities is well established. Attempts to improve service delivery in such areas as housing, health care and job training usually concentrate on ...
Dawkins, Cecilia E.
core   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

open access: yesMolecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma   +9 more
wiley   +1 more source

MicroRNA 196a contributes to the aggressiveness of esophageal adenocarcinoma through the MYC/TERT/NFκB axis

open access: yesMolecular Oncology, EarlyView.
mir‐196a promotes Esophagus Adenocarcinoma aggressiveness. On one hand, mir‐196a targets the valosin‐containing protein (VCP) mRNA, causing the accumulation of c‐MYC protein that leads to high amounts of TERT. On the other hand, mir‐196a targets the inhibitor of NFκB (NFKBIA).
Jesús García‐Castillo   +8 more
wiley   +1 more source

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