Results 121 to 130 of about 1,372,242 (337)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Perfil do idoso em área metropolitana na região sudeste do Brasil: resultados de inquérito domiciliar

Revista de Saúde Pública
Trata-se de estudo multicêntrico visando levantar as necessidades de saúde da população de idosos residentes em zona urbana, conduzido em 6 países na América Latina e coordenado pela Organização Panamericana da Saúde. No Brasil, 1.602 idosos (60 anos e +)
Luiz Roberto Ramos, Tereza Etsuko da C. Rosa, Zélia M. Oliveira, Maria Célia G. Medina, Francisco R. G. Santos   +4 more
doaj  

تقاضا وکشش جغرافیایی خدمات بستری سلامت در استان اصفهان با کمک سیستم اطلاعات جغرافیایی

مدیریت اطلاعات سلامت, 2014
مقدمه: تأمین دسترسی عادلانه به خدمات سلامت در قالب سطح‌بندی خدمات و نظام ارجاع از اهداف مهم توسعه‌ی کشور می‌باشد. این مطالعه با هدف تعیین الگوی تقاضا و کشش جغرافیایی خدمات بستری در منطقه‌ی تحت پوشش دانشگاه علوم پزشکی اصفهان در جهت کمک به سیاست‌گذاری ...
Elham MoazamFaramarz Gholami, Faramarz Gholami, Nafiseh Tavakol, Rafaat Zahedi Far   +3 more
doaj  

How many people will need palliative care in 2040? Past trends, future projections and implications for services

BMC Medicine, 2017
Background Current estimates suggest that approximately 75% of people approaching the end-of-life may benefit from palliative care. The growing numbers of older people and increasing prevalence of chronic illness in many countries mean that more people ...
S. N. Etkind, A. E. Bone, B. Gomes, N. Lovell, C. J. Evans, I. J. Higginson, F. E. M. Murtagh   +6 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Understanding the relationship between crime victimisation and mental health: a longitudinal analysis of population data [PDF]

Being a victim of violent crime has a damaging effect on mental health, particularly for women, according to this report. The needs and experiences of victims of crime have become increasingly recognised as an important aspect of criminal justice and ...
Karen Freeman, Nadine Smith
core  

Health care provision and equity [PDF]

, 2016
Equity is the absence of avoidable or remediable differences among groups of people that are defined socially, economically, demographically or geographically. It is fundamental to address these determinants in order to achieve equity in health.
Aljaberi, Musheer Abdulwahid, Esahak, Azreena, Ismail, Noor Haslinda, Juni, Muhamad Hanafiah, Saman @ Saimy, Intan Syafinaz, Wan, Arinah Deh Sze   +5 more
core  

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Unmet dental needs in children – a cross-sectional study of 0.6 million children in the United States

Family Medicine & Primary Care Review, 2021
Irene Rethemiotaki
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source