Results 81 to 90 of about 1,367,738 (299)

Maternal health in Jamaica : health needs, services, and utilization [PDF]

open access: yes
The main health issues for Jamaican women are nutrition, fertility, infection, chronic diseases, and stress and social problems. The two leading causes of adult health for women are cerebro-vascular accidents and coronary heart disease - of which high ...
Feifer, Chris Naschak
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Reducing need and demand for medical services in high-risk persons. A health education approach.

open access: yesThe Western journal of medicine, 1998
We undertook this study to identify persons with high medical use to target them for health promotion and self-management interventions specific to their problems. We compared the reductions in cost and health risk of a health education program aimed at high-risk persons with a similar program addressed to all risk levels.
J F, Fries, D, McShane
openaire   +1 more source

Revisiting the Most Informed Consumer of Surgical Services: The Physician-Patient [PDF]

open access: yes, 2017
Little is known about the consumption of medical and surgical services by the most informed consumer in the health care market: the physician-patient.
Casabianca, Antoine   +3 more
core  

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

Gênero e saúde no Brasil: considerações a partir da Pesquisa Nacional por Amostra de Domicílios

open access: yesRevista de Saúde Pública
A mulher brasileira tem vivido mais que o homem, como ocorre em países industrializados centrais. Nesses países, paradoxalmente, as mulheres apresentam indicadores de morbidade mais altos que os homens.
Estela M.L. Aquino   +2 more
doaj  

Quality pathology and laboratory diagnostic services are key to improving global health outcomes: improving global health outcomes is not possible without accurate disease diagnosis [PDF]

open access: yes, 2015
As the health care needs of populations change in low- and middle-income countries, the demand for affordable, accurate, and timely diagnostic testing will increase substantially. The need for such testing is threefold: (1) to guide treatment of patients,
Sayed, Shahin
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Priority setting for health in the context of devolution in Kenya: implications for health equity and community-based primary care [PDF]

open access: yes, 1996
Devolution changes the locus of power within a country from central to sub-national levels. In 2013, Kenya devolved health and other services from central government to 47 new sub-national governments (known as counties).
Rosalind McCollum   +69 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

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