Results 61 to 70 of about 174,424 (254)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Gênero e saúde no Brasil: considerações a partir da Pesquisa Nacional por Amostra de Domicílios

Revista de Saúde Pública
A mulher brasileira tem vivido mais que o homem, como ocorre em países industrializados centrais. Nesses países, paradoxalmente, as mulheres apresentam indicadores de morbidade mais altos que os homens.
Estela M.L. Aquino, Greice M.S. Menezes, Marúcia B. Amoedo   +2 more
doaj  

تقاضا وکشش جغرافیایی خدمات بستری سلامت در استان اصفهان با کمک سیستم اطلاعات جغرافیایی

مدیریت اطلاعات سلامت, 2014
مقدمه: تأمین دسترسی عادلانه به خدمات سلامت در قالب سطح‌بندی خدمات و نظام ارجاع از اهداف مهم توسعه‌ی کشور می‌باشد. این مطالعه با هدف تعیین الگوی تقاضا و کشش جغرافیایی خدمات بستری در منطقه‌ی تحت پوشش دانشگاه علوم پزشکی اصفهان در جهت کمک به سیاست‌گذاری ...
Elham MoazamFaramarz Gholami, Faramarz Gholami, Nafiseh Tavakol, Rafaat Zahedi Far   +3 more
doaj  

Hearing loss and use of health services: a population-based cross-sectional study among Finnish older adults

BMC Geriatrics, 2016
Background Older adults with hearing difficulties face problems of communication which may lead to underuse of health services. This study investigated the association of hearing loss and self-reported hearing difficulty with the use of health services ...
Tuija M. Mikkola, Hannele Polku, Päivi Sainio, Päivikki Koponen, Seppo Koskinen, Anne Viljanen   +5 more
doaj   +1 more source

Obstetric service demand is the main health need of the Vietnamese population in Guangxi, China: A cross-sectional study

Medicine
China has become an emerging destination for international migration, especially in some Association of South East Asian Nations countries, but the situation of migrants seeking medical care in China remains unclear. A retrospective cross-sectional study was conducted in a hospital in Chongzuo, which provides medical services for foreigners, to ...
Zhini Lan, Xiaoqiu Wu, Jiefang Huang, Cuizhu Pan, Jingzhen Lai, Xia Liang   +5 more
openaire   +2 more sources

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Perfil do idoso em área metropolitana na região sudeste do Brasil: resultados de inquérito domiciliar

Revista de Saúde Pública
Trata-se de estudo multicêntrico visando levantar as necessidades de saúde da população de idosos residentes em zona urbana, conduzido em 6 países na América Latina e coordenado pela Organização Panamericana da Saúde. No Brasil, 1.602 idosos (60 anos e +)
Luiz Roberto Ramos, Tereza Etsuko da C. Rosa, Zélia M. Oliveira, Maria Célia G. Medina, Francisco R. G. Santos   +4 more
doaj