Results 111 to 120 of about 77,141,905 (265)
Response to Sinn Féin Priorities for Change in Health & Social Care, 2023 [PDF]
We welcome the very considered priorities for change in health and social care that have been put together by Sinn Féin. Below are some suggestions to add to or modify those priorities.
Health Research Charities Ireland
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Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Public trust in health research: are we doing enough? Irish Health Research Forum recommendations and event report [PDF]
Public trust is essential for the health of the nation. Without it, people will reject, misunderstand or under-use the health research which can save and enhance their lives.
Health Research Charities Ireland
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Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
College of Health & Human Services professional schools
, 2020 Within the College of Health and Human Services (CHHS), three professional schools integrate teaching, community outreach, and research--the School of Health and Applied Human Sciences, the School of Nursing, and the School of Social ...
University of North Carolina, Wilmington. College of Health and Human Services
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USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
Health services research & development strategy discussion paper
, 2000 Synopsis Health Services Research means research into the delivery of health care and involves the investigation of the health needs of the population and the effectiveness and the efficiency of the provision of services to meet those needs.
Department of Public Health
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Health Research Board annual report 2019 [English and Irish versions]
, 2020 Key initiatives delivered during 2019 included: • Funding a selection of new and existing awards worth more than €38 million, which are aligned to our strategic priorities; some examples include: > Collaborative Doctoral Awards to support doctoral ...
Health Research Board
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Research towards a healthier Ireland. Health Research Charities Ireland Position Paper 2019 [PDF]
, 2019 In this document we present key priorities for HRCI and our members. We are asking politicians to take them on board in preparation for budget 2020 and in developing party manifestos for the next general election. These recommendations are based on: •
Health Research Charities Ireland, /
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