Results 101 to 110 of about 1,874,846 (315)

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Lightning Injury is a disaster in Bangladesh? - Exploring its magnitude and public health needs [version 1; referees: 3 approved, 1 approved with reservations]

F1000Research, 2016
Background: Lightning injury is a global public health issue. Low and middle-income countries in the tropical and subtropical regions of the world are most affected by lightning.
Animesh Biswas, Koustuv Dalal, Jahangir Hossain, Kamran Ul Baset, Fazlur Rahman, Saidur Rahman Mashreky   +5 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Healthcare choices in Mumbai slums: A cross-sectional study [version 2; referees: 1 approved, 2 approved with reservations]

Wellcome Open Research, 2018
Background: Informal urban settlements, known as slums, are the home for a large proportion of the world population. Healthcare in these environments is extremely complex, driven by poverty, environmental challenges, and poor access to formal health ...
Elina Naydenova, Arvind Raghu, Johanna Ernst, Sirazul A. Sahariah, Meera Gandhi, Georgina Murphy   +5 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Interventions at the end of life – a taxonomy for ‘overlapping consensus’ [version 1; referees: 2 approved]

Wellcome Open Research, 2017
Context: Around the world there is increasing interest in end of life issues. An unprecedented number of people dying in future decades will put new strains on families, communities, services and governments.
David Clark, Hamilton Inbadas, Ben Colburn, Catriona Forrest, Naomi Richards, Sandy Whitelaw, Shahaduz Zaman   +6 more
doaj   +1 more source

Public Private Partnership for Equitable Provision of Quality Health Services [PDF]

, 2005
This report presents the findings of an independent Technical Review that focused on the promotion of Public Private Partnership (PPP) for equitable provision of quality health services in Tanzania.
Health Research for Action, (HERA)
core  

Privatization and trade in health services: a review of the evidence.

, 2005
Health care provision, like other areas of welfare, has increasingly been subject to processes of privatization and contracting out, leading in some cases to an increased involvement of for-profit corporations.
Holden, Chris
core   +1 more source

A programme theory for liaison mental health services in England [PDF]

, 2018
Background Mechanisms by which liaison mental health services (LMHS) may bring about improved patient and organisational outcomes are poorly understood.
Martin, A, Elspeth Guthrie (7043729), Claire Hulme (3403817), Mike Crawford, Brennan, Cathy, Cathy Brennan (12573043), House, A, Matt Fossey (8716656), Carolyn C. Murray (16671771), Mike J. Crawford (5154629), Alan Quirk (4601884), Hewsion, Jenny, Jenny Hewsion, Tubeuf, Sandy, Adam Martin (2286838), Guthrie, E, Murray, Carolyn Czoski, Peter Trigwell (7043732), Elspeth Guthrie, Hulme, Claire, Andrew Walker (3042036), Walker, A, Claire Hulme, Quirk, Alan, Alan Quirk, Hewison, J, Hulme, C, Allan House, Cathy Brennan, Jenny Hewsion (16671768), House, Allan, Sandy Tubeuf (4440673), Brennan, C, Trigwell, Peter, Peter Trigwell, Czoski-Murray, C, Sandy Tubeuf, Guthrie, Elspeth, Carolyn Czoski Murray, Crawford, M, Matt Fossey, Allan House (3439343), Andrew Walker, Adam Martin, Crawford, Mike, Martin, Adam, Quirk, A, Tubeuf, S, Walker, Andrew, Fossey, M, Fossey, Matt, Murray, CC, Hewsion, J, Trigwell, P   +53 more
core   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source