Results 81 to 90 of about 1,874,846 (315)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

The Evolution of Health Services Research [PDF]

Health Services Research, 2013
The field of health services research is poised for a major sea change. It is not so much that researchers are being asked to focus on new topic areas as that the role that they are expected to play in conducting research is evolving. The implementation of provisions within the Affordable Care Act (ACA) will encourage a greater partnership than has ...
openaire   +4 more sources

The influences of Taiwan's National Health Insurance on women's choice of prenatal care facility: Investigation of differences between rural and non-rural areas

, 2008
[[abstract]]Background: Taiwan's National Health Insurance (NHI), implemented in 1995, substantially increased the number of health care facilities that can deliver free prenatal care.
Chen, L; Chen, CL; Yang, WC
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Morbidade referida e utilização de serviços de saúde em localidades urbanas brasileiras: metodologia

Revista de Saúde Pública
A reformulação do sistema de saúde, que vem ocorrendo em nível nacional e particularmente no Estado de São Paulo, tem motivado revisões do processo de planejamento, criando novas necessidades na área de informações.
Chester L. G. Cesar, Gerusa Maria Figueiredo, Márcia F. Westphal, Maria Regina A. Cardoso, Maria Zilda de A. Costa, Vera Lucia Gattás   +5 more
doaj  

Health services research doctoral core competencies

BMC Health Services Research, 2009
This manuscript presents an initial description of doctoral level core competencies for health services research (HSR). The competencies were developed by a review of the literature, text analysis of institutional accreditation self-studies submitted to ...
Holve Erin, Martin Diane P, Forrest Christopher B, Millman Anne   +3 more
doaj   +1 more source

College of Health & Human Services professional schools

, 2020
Within the College of Health and Human Services (CHHS), three professional schools integrate teaching, community outreach, and research--the School of Health and Applied Human Sciences, the School of Nursing, and the School of Social ...
University of North Carolina, Wilmington. College of Health and Human Services
core  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Failure to Rescue as an Outcome Metric for Pediatric and Congenital Cardiac Catheterization Laboratory Programs: Analysis of Data From the IMPACT Registry

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Risk‐adjusted adverse event (AE) rates have been used to measure the quality of pediatric and congenital cardiac catheterization laboratories. In other settings, failure to rescue (FTR) has demonstrated utility as a quality metric. Methods and
Michael L. O'Byrne, Kevin F. Kennedy, Natalie Jayaram, Lisa J. Bergersen, Matthew J. Gillespie, Yoav Dori, Jeffrey H. Silber, Steven M. Kawut, Jonathan J. Rome, Andrew C Glatz   +9 more
doaj   +1 more source

Health services research in Australia [PDF]

Australian Health Review, 2001
The long-awaited Wills Implementation Committee Report (CoA 2000), which was completed by Novemberlast year, has now been released. Wills' earlier Report (CoA 1998) identified the need for the development ofhealth services research capacity in Australia, and this new Report recommends how this should be done,through the establishment and support of ...
openaire   +2 more sources