Results 71 to 80 of about 77,141,905 (265)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Research governance: a guide for health research charities
, 2021 Health research charities are important leaders in research which addresses the unmet health needs of patients and the public. Much of the funding that goes into research by charities has been donated by their members or supporters who wish to make a ...
Health Research Charities Ireland
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Wellcome Open Research, 2018 Background: Decentralization of health systems has made sub-national/regional healthcare systems the backbone of healthcare delivery. These regions are tasked with the difficult responsibility of determining healthcare priorities and resource allocation ...
Dennis Waithaka +2 more
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
How to be responsive and resilient in the face of crises. Irish Health Research Forum recommendations and event report [PDF]
, 2022 This report presents the proceedings of the Irish Health Research Forum held on November 17th, 2021. The event provided an opportunity for reflection on the challenges that the health research community faced in 2020 and 2021: namely Covid and the cyber-
Health Research Charities Ireland
core
F1000Research, 2014 Hand hygiene has been shown to be effective in significantly reducing hospital acquired infections for many years. However it is difficult to maintain and enhance compliance with hand hygiene guidelines. In Hong Kong, we previously reported a strategy to
Wing Hong Seto +4 more
doaj +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
INTEGRATED HEALTH SERVICE DELIVERY: WHY AND HOW?
National Journal of Medical Research, 2013 Integrated service delivery is an approach of combining services of multiple interrelated diseases to increase overall efficiency of the health system and patient convenience.
Satya Ranjan Lenka, Bitra George
doaj
F1000Research, 2013 This paper focuses on financial incentives rewarding successful implementation of guidelines in the UK National Health Service (NHS). In particular, it assesses the implementation of National Institute for Health and Clinical Excellence (NICE) venous ...
Sue Child +4 more
doaj +1 more source