Results 91 to 100 of about 77,141,905 (265)
Celebrating 10 years of the Irish Health Research Forum 2014-2024 [PDF]
This is a brief overview of the success of the Irish Health Research Forum over 10 years since its foundation in ...
Health Research Charities Ireland
core
Health services research doctoral core competencies
BMC Health Services Research, 2009 This manuscript presents an initial description of doctoral level core competencies for health services research (HSR). The competencies were developed by a review of the literature, text analysis of institutional accreditation self-studies submitted to ...
Holve Erin +3 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019 Background Risk‐adjusted adverse event (AE) rates have been used to measure the quality of pediatric and congenital cardiac catheterization laboratories. In other settings, failure to rescue (FTR) has demonstrated utility as a quality metric. Methods and
Michael L. O'Byrne +9 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Biobanking in Ireland: Moving Forward. Irish Health Research Forum Recommendations and Event Report [PDF]
This report presents the proceedings of the Irish Health Research Forum on November 16th 2023, focusing on progressing biobanking in Ireland, and makes key recommendations for moving biobanking forward.Roche Products ...
Health Research Charities Ireland
core
Building health research systems to achieve better health [PDF]
, 2006 Health research systems can link knowledge generation with practical concerns to improve health and health equity. Interest in health research, and in how health research systems should best be organised, is moving up the agenda of bodies such as the ...
Hanney, S, Gonzalez-Block, MA
core +2 more sources
Utilization of dental services by preschool children: prevalence and associated factors [PDF]
Brazilian Oral ResearchDental associations worldwide recommend that the first dental visit should take place before 12 months of age; however, preschoolers’ utilization of dental services remains low.
Isabela da Costa GONÇALVES +6 more
doaj +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Empower, innovate, transform: driving the future of health research. 10th anniversary of the Irish Health Research Forum. Recommendations and Event Report [PDF]
This landmark event for the Irish Health Research Forum offered an opportunity to reflect on the key issues addressed by past Forum events and, in particular, to identify the recurring themes that have emerged from the recommendations generated from ...
Health Research Charities Ireland
core +1 more source