Results 91 to 100 of about 4,802,621 (302)

Mesh inlay, mesh kit or native tissue repair for women having repeat anterior or posterior prolapse surgery: randomised controlled trial (PROSPECT) [PDF]

, 2020
Funding The project was funded by the National Institute for Health Research Health Technology Assessment Programme (Project Number 07/60/18). The Health Services Research Unit and the Health Economics Research Unit are funded by the Chief Scientist ...
Boyers, D, Breeman, S, Cooper, K G, Elders, A, Freeman, R M, Glazener, CMA, Hagen, S, Hemming, C, Kilonzo, M, MacLennan, G, McDonald, A, McPherson, G, Montgomery, I, Norrie, J, PROSPECT study group, Reid, F M, Smith, ARB   +16 more
core   +4 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Morbidade referida e utilização de serviços de saúde em localidades urbanas brasileiras: metodologia

Revista de Saúde Pública
A reformulação do sistema de saúde, que vem ocorrendo em nível nacional e particularmente no Estado de São Paulo, tem motivado revisões do processo de planejamento, criando novas necessidades na área de informações.
Chester L. G. Cesar, Gerusa Maria Figueiredo, Márcia F. Westphal, Maria Regina A. Cardoso, Maria Zilda de A. Costa, Vera Lucia Gattás   +5 more
doaj  

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Failure to Rescue as an Outcome Metric for Pediatric and Congenital Cardiac Catheterization Laboratory Programs: Analysis of Data From the IMPACT Registry

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Risk‐adjusted adverse event (AE) rates have been used to measure the quality of pediatric and congenital cardiac catheterization laboratories. In other settings, failure to rescue (FTR) has demonstrated utility as a quality metric. Methods and
Michael L. O'Byrne, Kevin F. Kennedy, Natalie Jayaram, Lisa J. Bergersen, Matthew J. Gillespie, Yoav Dori, Jeffrey H. Silber, Steven M. Kawut, Jonathan J. Rome, Andrew C Glatz   +9 more
doaj   +1 more source

Justice Data Base Directory [PDF]

, 1992
The Justice Data Base Directory was originally published in 1988 with an introduction, 8 chapters describing Alaska justice agencies and their data holdings, and an index. It was published in looseleaf notebook format for easy updating. Four updates were
Alaska Justice Statistical Analysis Unit, Moras, Antonia   +1 more
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Utilization of dental services by preschool children: prevalence and associated factors [PDF]

Brazilian Oral Research
Dental associations worldwide recommend that the first dental visit should take place before 12 months of age; however, preschoolers’ utilization of dental services remains low.
Isabela da Costa GONÇALVES, Valéria Silveira COELHO, Joana RAMOS-JORGE, Priscila Seixas MOURÃO, Kaio Henrique SOARES, Maria Letícia RAMOS-JORGE, Izabella Barbosa FERNANDES   +6 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Putting Health Services Research into Practice

Proceedings of Singapore Healthcare, 2011
Health services research (HSR) seeks to shed light on healthcare as a system, focusing on the cost of, the quality of and access to health services. While there is recognition that the practice of medicine should be evidence-based, there has been limited
Wai Ling Chow GDFM (Singapore), MBBS (Singapore), Jeremy Fung Yen Lim MBBS, MPH   +1 more
doaj   +1 more source