Discerning protein pools by selective staining with self‐labeling tags
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Summary health statistics for U.S. children; National Health Interview Survey, 1997 [PDF]
"December, 2001."Barbara Bloom, M.P.A., and Luong Tonthat, Division of Health Interview Statistics."This report presents statistics derived from the 1997 National Health Interview Survey on selected health measures for sample children under 18 years of ...
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Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Health characteristics of patients with asthma, COPD and asthma–COPD overlap in the NHANES database
Jean-Pierre Llanos,1 Hector Ortega,2 Guillaume Germain,3 Mei Sheng Duh,4 Marie-Helene Lafeuille,3 Sean Tiggelaar,3 Christopher F Bell1, Beth Hahn1 1US Medical Affairs, GSK, Research Triangle Park, NC, USA; 2US Medical Affairs, GSK, La Jolla, CA, USA ...
Llanos JP +7 more
doaj
Summary health statistics for the U.S. population : National Health Interview Survey, 2008 : data from the National Health Interview Survey [PDF]
"This report presents both age-adjusted and unadjusted health statistics from the 2008 National Health Interview Survey (NHIS) for the civilian noninstitutionalized population of the United States, classified by sex, age, race, Hispanic or Latino origin ...
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
1996 Health Status Survey - Health Insurance Coverage
Health care in America is financed primarily through a mix of public and private insurance, but many still lack financial access to basic services and financial protection against the high costs of illness.
Utah Department of Health, Bureau of Surveillance and Analysis
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Liver organoids: modelling complexity in homeostasis and disease
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Health Status and Health Care Access of Farm and Rural Populations [PDF]
Rural residents have higher rates of age-adjusted mortality, disability, and chronic disease than their urban counterparts, though mortality and disability rates vary more by region than by metro status.
Variyam, Jayachandran N. +4 more
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